alexa Building the Regenerative Microenvironment with Functional Biomaterials for Spinal Cord Injury Repair | OMICS International | Abstract
ISSN: 2165-7939

Journal of Spine
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Review Article

Building the Regenerative Microenvironment with Functional Biomaterials for Spinal Cord Injury Repair

Zhifeng Xiao#, Bing Chen# and Jianwu Dai*

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
#These authors contributed equally

*Corresponding Author : Jianwu Dai
Institute of Genetics and Developmental Biology
Chinese Academy of Sciences
3 Nanyitiao, Zhongguancun
Beijing 100190, PR China
Tel: 86-10-82614426
Fax: 86-10-82614420
E-mail: [email protected]
Received: February 10, 2016; Accepted: March 08, 2016; Published: March 10, 2016
Citation: Xiao Z, Chen B, Dai J (2016) Building the Regenerative Microenvironment with Functional Biomaterials for Spinal Cord Injury Repair. J Spine S7:005. doi:10.4172/2165-7939.S7-005
Copyright: © 2016 Xiao Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Spinal cord injury (SCI) is a devastating injury resulting in changes in the spinal cord’s motor, sensory, or autonomic functions. Following SCI, an inhibitory environment develops at the injury site for neural regeneration. In this review, we summary the strategies to rebuild the regenerative microenvironment with functional biomaterials for SCI repair mainly based on our research. We have developed a functional biomaterial consisting of collagen scaffolds and biologically active molecules (neurotrophic factor or the antagonists to myelin-associated inhibitor), and stem cells to rebuild a nerve regeneration microenvironment. Specifically, (1) the linear ordered collagen scaffold (LOCS) was used to guide the neural regeneration along its fibers and decrease the formation of glial scars, (2) collagen binding neurotrophic factors were incorporated into the scaffolds to promote neuronal survival and neural fiber regeneration, (3) antagonists to myelin-associated inhibitors were added to the scaffold to direct the neuronal differentiation of the native or transplanted neural stem cells at the injury site, (4) mesenchymal stem cells (MSCs) were also added to the scaffold to reduce the acute inflammatory response due to SCI. These strategies were found to promote neural regeneration and functional recovery in SCI animals. In addition, the endogenous neural stem cells (NSCs) or implanted NSCs could be differentiated into neurons, which re-established the neuronal circuits to improve SCI repair under the favorable environment.

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