alexa C358A Polymorphism of the Endocannabinoid Degrading Enz
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

C358A Polymorphism of the Endocannabinoid Degrading Enzyme Fatty Acid Amide Hydrolase (FAAH) Influence On Metabolic Parameters a High Protein/Low Carbohydrate versus a Standard Hypocaloric Diet

R Aller, O Izaola, R Bachiller, E Romero and DA de Luis*
Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain
*Corresponding Author : Dr. D. A de Luis
Professor Associated of Nutrition
Executive Director of Institute of Endocrinology and Nutrition
Medicine School, Valladolid University
C/Los perales 16, Simancas 47130
Valladolid, Spain
Tel: +34983423000
E-mail: [email protected]
Received January 11, 2016; Accepted January 30, 2016; Published February 01, 2016
Citation: Aller R, Izaola O, Bachiller R, Romero E, de Luis DA (2016) C358A Polymorphism of the Endocannabinoid Degrading Enzyme Fatty Acid Amide Hydrolase (FAAH) Influence On Metabolic Parameters a High Protein/Low Carbohydrate versus a Standard Hypocaloric Diet. J Metabolic Synd 5:197. doi:10.4172/2167-0943.1000197
Copyright: © 2016 Aller R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background and aim: The C385A polymorphism of FAAH gene (rs324420C>A) has been associated with obesity. We investigate the role of this polymorphism on cardiovascular risk factors and weight loss secondary to a high protein/ low carbohydrate vs. a standard hypocaloric diets (1000 kcal/day) during 9 months.
Methods: A sample of 284 subjects with obesity (body mass index (BMI) >30) was enrolled. These subjects were randomly allocated to one of two diets for a period of nine months Diet S (standard protein hypocaloric diet) vs. Diet HP (high protein-low carbohydrate hypocaloric diet).
Results: After both diets and in both genotype groups (CC vs. CA+AA), body mass index (BMI), weight, fat mass, waist circumference and systolic blood pressure decreased. With the diet type HP and in non A carriers, glucose (-5.3 ± 1.2 mg/dl vs. -1.8 ± 2.1 mg/dl; p<0.05), insulin levels (-3.1 ± 1.9UI/L vs. -1.1 ± 2.0 UI/L; p<0.05), HOMA-R (-0.9 ± 0.8 units vs. -0.3 ± 1.0 units; p<0.05), total cholesterol (-11.9 ± 8.2 mg/dl vs. -0.1 ± 3.1mg/dl; p<0.05), and LDL- total cholesterol (-9.8 ± 4.2 mg/dl vs. -1.0 ± 2.1mg/dl; p<0.05) decreased. After diet S and in patients with both genotypes, total cholesterol (-6.0 ± 3.1 mg/dl vs. -10.0 ± 8.2mg/dl; ns), triglycerides (-8.1 ± 7.1 mg/dl vs. -13.1 ± 8.9 mg/dl; ns) and LDL- total cholesterol (-5.9 ± 3.0 mg/dl vs. -9.1 ± 5.8mg/dl; p<0.05) decreased.
Conclusion: Non carriers of the allele A385 of FAAH showed an improvement on insulin and HOMA-R levels with a high protein hypocaloric diet after weight loss during 9 months. A standard hypocaloric diet produced a similar improvement in lipid profile in both genotypes.

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