alexa C60 Fluorine Derivative as Novel Matrix for Small Molecule Analysis by MALDI-TOF MS
ISSN: 2153-0769

Metabolomics:Open Access
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Research Article

C60 Fluorine Derivative as Novel Matrix for Small Molecule Analysis by MALDI-TOF MS

Jian An Liu1, Lei Xiong2, Shu Zhang1, Jing Chao Wei1 and Shao Xiang Xiong1*

1Beijing Mass Spectrometry Center, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

2AB SCIEX, 500 Old Connecticut Path, Framingham, MA, 01701, USA

*Corresponding Author:
Shao Xiang Xiong
Beijing Mass Spectrometry Center
Institute of Chemistry
Chinese Academy of Sciences
Beijing 100190, China
E-mail: [email protected]

Received date: March 08, 2012; Accepted date: March 29, 2012; Published date: March 31, 2012

Citation: Liu JA, Xiong L, Zhang S, Wei JC, Xiong SX (2012) C60 Fluorine Derivative as Novel Matrix for Small Molecule Analysis by MALDI-TOF MS. Metabolomics S1:002. doi: 10.4172/2153-0769.S1-002

Copyright: © 2012 Liu JA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is an efficient tool for large molecule analysis including proteins, carbohydrates, polymers etc., with the advantages of high sensitivity, high throughput and high speed. However, the traditional matrices, such as α-cyano-4-hydroxycinnamic acid (CHCA) and 2,5-dihydroxybenzoic acid (DHB), fail to detect the compounds with molecular weight below 500 Da due to the interference from matrix background. In this paper, we used C60 fluorine derivative as matrix for small molecule analysis by MALDI-TOF MS. With the successful detection of various small molecules from saccharides, plant extracts, fatty acids, amino acids to pesticides, C60 derivative is reported here for the first time as a novel and effective MALDI matrix for small molecule analysis in metabolism and compound characterization areas.

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