alexa c.+62G>A and g.-420C>G RETN Polymorphisms and the Risk
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
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Research Article

c.+62G>A and g.-420C>G RETN Polymorphisms and the Risk of Developing Type 2 Diabetes and Obesity: Original Research on a Mexican Population and Meta-analysis

Pablo A. Montiel-Tellez BS1, Adriana Nieva-Vazquez1, Leonardo M. Porchia2, Elba Gonzalez-Mejia M1, Enrique Torres-Rasgado1, Guadalupe Ruiz-Vivanco1,3 and Ricardo Perez-Fuentes1,2*

1Autonomous University of Puebla, 13 Sur 2901 Col. Volcanoes, C.P. 72000, Puebla, Mexico

2Laboratorio Research Pathophysiology of Chronic Diseases, Center for Biomedical Research East, IMSS, Km 4.5 Carretera Federal Atlixco- Metepec, C.P. 42730, Atlixco, Puebla, Mexico

3Tlaxcala Center for Behavioral Biology, University of Tlaxcala. Federal highway Tlaxcala - Puebla, Mexico

Corresponding Author:
Ricardo Pérez-Fuentes
Facultad de Medicina
Benemérita Universidad Autónoma de Puebla
13 Sur 2901 Col. Volcanes
C.P. 72000, Puebla, Pue, México
Tel: +52 (222) 244 44 122
E-Mail: [email protected]

Received Date: January 26, 2016; Accepted Date: March 04, 2016; Published Date: March 11, 2016

Citation: Montiel-Tellez BSPA, Nieva-Vazquez A, Porchia LM, Gonzalez-Mejia EM, Torres-Rasgado E, et al. (2016) Ec.+62G>A and g.-420C>G RETNPolymorphisms and the Risk of Developing Type 2 Diabetes and Obesity: Original Research on a Mexican Population and Meta-analysis. Endocrinol Metab Syndr 5:228. doi:10.4172/2161-1017.1000228

Copyright: © 2016 Montiel-Tellez BSPA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: To determine the association between the c.+62G>A and g.-420C>G polymorphisms and Type 2 Diabetes (T2D) or obesity susceptibility for Mexicans. Additionally, we examined their overall effect across different populations by a systematic review. Methods: 164 Mexicans were classified as Healthy, Obese, or T2D. Genotypes were determined and associated risk for the heterozygous, homozygous, dominant, recessive, and allelic genetic models were determined by calculating the Odds Ratios (OR). For the meta-analysis, original publications that had determined RETN polymorphisms in T2D or obese subjects were searched for in PubMed, Scopus, EBSCO, Ovid, and Wiley databases until November 2015, using the search terms: T2D, obesity, RETN, and polymorphism. Pooled ORs were computed using a random-effects or fixed-effects models. Results: For our cohort, no associations were observed between the polymorphisms and obesity or T2D. The metaanalysis indicates an increased risk of obesity among carriers of the g.-420G allele for the heterozygous and dominant models (OR=1.33 and OR=1.30, p<0.05, respectively). By regional assessment, Africans were associated with an elevated risk of developing T2D (OR=2.35-7.17, p<0.05) and obesity (OR=1.54-2.13, p<0.05). North Americans had an increased risk of developing obesity for the heterozygous and dominant models (OR=1.49and OR=1.42, p<0.05, respectively). No associations were determined between the c.+62 polymorphism and obesity or T2D. Conclusion: For Mexicans, none of the polymorphisms were associated with a risk of developing obesity or T2D. However, there is an increased risk of developing obesity for the whole population for subjects who carry the g.-420G allele.

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