alexa Ca2+ signaling and Target Binding Regulations: Calmodulin and Centrin In Vitroand In Vivo
ISSN: 2167-7662

Bioenergetics: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Ca2+ signaling and Target Binding Regulations: Calmodulin and Centrin In Vitroand In Vivo

Juan Martinez-Sanz1,2,3, Dora Grecu1,2 and Liliane Assairi1,2*

1Institute Curie-Research Center, F-91405 Orsay Cedex, France

2National Institute of Health and Medical Research (INSERM) U759, F-91405 Orsay Cedex, France

3UMR9187-U1196, F-91405 Orsay Cedex, France

Corresponding Author:
Assairi L
Institut Curie, Research Center, INSERM U759
15 Rue Georges Clemenceau, University Center Orsay
Building 112, F-91405 Orsay Cedex, France
Tel: +33169863178
Fax: +33169075327
E-mail: [email protected]

Received Date: March 28, 2016; Accepted Date: December 22, 2016; Published Date: December 26, 2016

Citation: Martinez-Sanz J, Grecu D, Assairi L (2016) Ca2+ signaling and Target Binding Regulations: Calmodulin and Centrin In Vitro and In Vivo. Bioenergetics 5:144. doi:10.4172/2167-7662.1000144

Copyright: © 2016 Martinez-Sanz J et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Changes in Ca2+ concentrations act as a second messenger to regulate biological processes. Ca2+ sensor proteins transduce these Ca2+ signals upon binding to protein targets that are involved in the cellular process that is being regulated.

Ca2+ sensor proteins such as calmodulin and centrin bind Ca2+ through acidic residues that compose the EFhand motifs and further bind targets via surfaces that recognize specific motifs on targets. However, in some cases, the binding of a Ca2+ sensor protein to a target can occur in the absence of Ca2+. Upon Ca2+ binding, Ca2+-sensor proteins undergo conformational changes, which lead to the exposure of surface that interacts with target. Moreover, Ca2+ binding and the binding of Ca2+ sensors to targets induce conformational changes that drive regulation. Comparisons of the Ca2+-sensor proteins calmodulin and centrin provide information on regulatory processes.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]sonline.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords