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Caenorhabditis elegans: An Emerging Model System for Pesticide Neurotoxicity | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Review Article

Caenorhabditis elegans: An Emerging Model System for Pesticide Neurotoxicity

KA McVey, JA Mink, IB Snapp, WS Timberlake, CE Todt, R Negga and VA Fitsanakis*
King College, Department of Biology,1350 King College Road, Bristol, TN 37620, USA
Corresponding Author : VA Fitsanakis
King College, Department of Biology
1350 King College Road, Bristol
TN 37620, USA
Tel: 423-652-6322
Fax: 423-652-4833
E-mail: [email protected]
Received December 07, 2011; Accepted February 14, 2012; Published February 16, 2012
Citation: McVey KA, Mink JA, Snapp IB, Timberlake WS, Todt CE, et al. (2012) Caenorhabditis elegans: An Emerging Model System for Pesticide Neurotoxicity. J Environment Analytic Toxicol S4:003. doi: 10.4172/2161-0525.S4-003
Copyright: © 2012 McVey KA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


An ideal model organism should generally have three essential characteristics: successful sexual crosses should be easy to perform; a fully sequenced genome should be available; and it should be easy to induce reliable and reproducible DNA mutations. The nematode Caenorhabditis elegans (C. elegans), introduced to the broad scientific community by Brenner in 1974, fulfills each of these three essential guidelines. Although initially used extensively by the developmental biology community, its recent adoption by the biomedical and environmental toxicology scientists has strengthened experimental design power in these fields. Relative to traditional model organisms, e.g. rat, mouse, dog (mammals) and Arabidopsis (plants), the invertebrate species C. elegans has begun to be recognized as invaluable. For example, it requires a relatively small budget project compared to other possible organisms, is quite small and transparent, has a short lifespan and has relatively simple anatomy and physiology.

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