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Calcified Granulomatous Lung Lesions Contain Abundant Mycobacterium tuberculosis Components | OMICS International | Abstract
ISSN: 2161-1068

Mycobacterial Diseases
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Research Article

Calcified Granulomatous Lung Lesions Contain Abundant Mycobacterium tuberculosis Components

Tadatsune Iida1, Keisuke Uchida1, Nilufar Lokman1, Asuka Furukawa1, Yoshimi Suzuki1, Toshio Kumasaka2, Tamiko Takemura2, Hiroshi Kawachi1, Takumi Akashi3 and Yoshinobu Eishi1,3*

1Department of Human Pathology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan

2Department of Pathology, Japanese Red Cross Medical Center, Tokyo, Japan

3Division of Surgical Pathology, Tokyo Medical and Dental University Hospital, Tokyo, Japan

Corresponding Author:
Yoshinobu Eishi
Department of Human pathology, Division of Surgical Pathology
Tokyo Medical and Dental University, 1-5-45
Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan
Tel: +81-3-5803-5177
Fax: +81-3-5803-0123
E-mail: [email protected]

Received Date: December 22, 2013; Accepted Date: January 26, 2014; Published Date: February 01, 2014

Citation: Iida T, Uchida K, Lokman N, Furukawa A, Suzuki Y, et al. (2014) Calcified Granulomatous Lung Lesions Contain Abundant Mycobacterium tuberculosis Components. J Mycobac Dis 4:142. doi:10.4172/2161-1068.1000142

Copyright: © 2014 Iida T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Mycobacterium tuberculosis can survive for a long time in the body of a healthy host, causing no symptoms after primary infection. Years or decades later, M. tuberculosis can be reactivated in some carriers, leading to symptoms of post-primary tuberculosis. During the asymptomatic period, M. tuberculosis is believed to survive in old foci of infection, yet these foci are uniformly negative by culture and acid-fast staining, which are conventional methods to detect mycobacteria. The precise location and amount of M. tuberculosis in these foci, therefore, are not well understood. Here we report that granulomatous lesions with calcification, a well-known characteristic of old tubercles, contained considerable amounts of M. tuberculosis genomes and cell wall components. These calcified lesions exhibited little inflammation but all were positive for M. tuberculosis by real-time polymerase chain reaction and by immunohistochemistry with a novel monoclonal antibody against lipoarabinomannan, a cell wall component of mycobacteria. We found many lipoarabinomannan-containing granules in the necrotic areas of the lesions that were negative by Ziehl-Neelsen staining but included some bacillus-like structures. The risk of reactivation of latent tuberculosis from these calcified granulomatous lung lesions should be considered.