Can a Vibratory Back Massage Induce Neo-Coronary Growth? A Blinded, Randomized Controlled Pilot Study Protocol
|Andrew Hoffmann1* and Harjit Gill2|
|1Ahof Biophysical Systems Inc., Department of Research and Development, 3858 Regent St., Burnaby, B.C., V5C 4G8, Canada|
|2In-Vitro Laboratories, 5407 Canada Way, Burnaby, BC, V5E 3N5, Canada|
|Corresponding Author :||Andrew Hoffmann
Ahof Biophysical Systems Inc.
Department of Research and Development
3858 Regent St., Burnaby, B.C., V5V 4G8, Canada
E-mail: [email protected]
|Received April 16, 2015; Accepted August 26, 2015; Published August 31, 2015|
|Citation: Hoffmann A, Gill H (2015) Can a Vibratory Back Massage Induce Neo-Coronary Growth? A Blinded, Randomized Controlled Pilot Study Protocol. J Clin Exp Cardiolog 6:394. doi:10.4172/2155-9880.1000394|
|Copyright: © 2015 Hoffmann A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Coronary artery disease (CAD) is a leading source of death and morbidity, and the search continues for viable therapeutic options to stimulate new coronary growth. Low frequency vibration (LFV) can induce fluid sheer forces and cyclic stretch/strain to vascular endothelial cells and extracellular matrix which is known to up-regulate expression of pro-angiogenic mediators such as nitric oxide, vascular endothelial growth factor, and other sheer responsive proteins. Further, cyclic stretch of coronary microvascular cells has shown to induce coronary angiogenesis in-vitro, and LFV promoted arteriogenesis has recently been demonstrated in-vivo. Interestingly there has been no work to address whether transthoracic LFV massage could induce neo-coronary growth in CAD patients. We therefore present a single center, prospective, blinded, randomized, controlled pilot study protocol aiming to test whether penetrative LFV (35 Hz) applied to the upper back of refractory angina (RFA) and/or ischemic heart failure (IHF) patients (by daily 30 minute sessions, over a 3 month period) may enhance lasting myocardial perfusion and improve clinical outcomes.