Can Microfluidics boost the Map of Glycome Code?
Center for Advanced Biomaterials for Health Care Italian Institute of Technology, Italy
- *Corresponding Author:
- Dr. Giuseppina Simone
Center for Advanced Biomaterials for Health CareItalian Institute of Technology
CRIBLargo Barsanti e Matteucci, 53- 80125 - Naples, Italy
Tel: +39 081 199 331 00
Fax: +39 0817682404
E-mail: giuseppin[email protected]
Received Date: October 10, 2013; Accepted Date: January 13, 2014; Published Date: January 16, 2014
Citation: Simone G (2014) Can Microfluidics boost the Map of Glycome Code? J Glycomics Lipidomics 4:110. doi: 10.4172/2153-0637.1000110
Copyright: © 2014 Simone G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Proteins carry out pivotal functions in cells. Less appreciated is that the proteins are sugar coated and that
glycosylation affects how the immune system recognizes the protein, as being friend or foe. Unlike proteomics, glycomics
is not identified by structures and sequence of the single units is not predefined. This makes difficult and tricky the study
of glycosylation and glycoproteomics. However, the role of glycome code on cellular mechanisms cannot be neglected.
Glycosylation of proteins is a major event in posttranslational processing along their route, cell surface proteins are mainly
glycoproteins. Hence, glycosylation changes and glycan-protein interactions feature malignant transformation and tumor
progression. The distance between glycomics and proteomics is still far and it is missed the methodological approach to
pinpoint the site where glycosylation takes place.
Here, glycomics and glycoproteomics are analyzed and the role that microfluidics can play in research is investigated
by the description of the already reported application. The margins of improvement of microfluidics are still wide. Here,
analyzing the structural hierarchical levels, we intend critically discuss the role that microfluidics might have in boosting
knowledge and progress in glycoscience.