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Can Standardized Plant Extracts Induce Complete Remission in Patients with Metastatic Tumors? | OMICS International | Abstract
ISSN: 2327-5162

Alternative & Integrative Medicine
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Research Article

Can Standardized Plant Extracts Induce Complete Remission in Patients with Metastatic Tumors?

Tibor Hajtó1*, András Adámy1, Lilla Baranyai1, Zoltán Langmár2, Angelika Kirsch3, Monika Kuzma1, Lajos Ábrahám4 and Perjési Pál1

1Institute of Pharmaceutical Chemistry, Medical University Pecs, Hungary

22nd Department of Gynecology, Semmelweis University, Budapest, Hungary

3Private Practice, Arlesheim, Switzerland

4Surgical Department of Szent János Hospital Budapest, Hungary

*Corresponding Author:
Tibor Hajtó, MD, PhD
Károly krt. 3/C, H-1075 Budapest, Hungary
Tel: 0036-309-735-337
E-mail: [email protected]

Received date February 28, 2014; Accepted date May 01, 2014; Published date May 03, 2014

Citation: Hajtó T, Adámy A, Baranyai L, Langmár Z, Kirsch A, et al. (2014) Can Standardized Plant Extracts Induce Complete Remission in Patients with Metastatic Tumors?. Altern Integr Med 3:161. doi:10.4172/2327-5162.1000161

Copyright: © 2014 Hajtó T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: The prognostic significance of malignant tumor-induced imbalance in the innate immune system is well known. The innate system uses a limited number of Pattern Recognition Receptors (PRR) to recognize conserved Pathogenic Associated Molecular Pattern (PAMP) structures expressed by microbes but not by host. PRR engagement often leads to the activation of natural immune cells which are important in the tumor defense. Growing evidence supports the hypothesis that similar to microbes various plant extracts can also contain PAMP-like structures which can activate cellular immune functions. Since the chemical production of PAMP structures is hardly accomplishable, the phytotherapy may be promising for the future tumor therapy. Objectives: The aim of this article is to present and discuss several favorable clinical responses of tumor patients treated with immunologically effective and standardized plant extracts (containing PAMP-like structures) as an addition to the conventional oncologic therapy. Course of therapy and results: Two standardized plant preparations based on lectin-sugar interactions were the patients given. The dose of the active sugar-binding mistletoe lectin (ML), applied subcutaneously by standardized mistletoe extract (ME) preparations, was between 0.5 and 1.0 ng/kg and the dose of arabinoxylan (given by standardized rice bran preparation, MGN-3/Biobran) was between 12 and 45mg/kg twice a week. In addition, wheat germ extract (WGE) standardized for 2, 6-dimethoxy-p-benzoquinone (50-80 mg/kg Avemar four times a week) was also given which can sensitize tumor cells against natural immune effector cells. Case reports gave an account of complete or nearly complete remissions in patients with sarcoma or with hepatic metastases treated with these standardized plant immunomodulators with and without conventional oncologic therapy. Conclusion: Standardized plant extracts (such as ME/ML, MGN-3 and WGE) seem to be potent candidates to be regarded as a supportive therapy of metastatic tumors  


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