alexa Can We Control the Progression of HIV by Monitor Markers of Microbial Translocation?
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
Open Access

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Review Article

Can We Control the Progression of HIV by Monitor Markers of Microbial Translocation?

Wen-jun Zhang, Zhi-hong Guo, Jia-feng Zhang, Jun Jiang and Xiao-hong Pan*

Department of HIV/AIDS & STD control and prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, 310051, P.R.China

*Corresponding Author:
Xiao-hong Pan
Zhejiang Provincial Center for Disease
Control and Prevention No.3399
Binsheng Road, Hangzhou
310051, P.R.China
Fax: 86-057-87115190
Tel: 86-0571-87115190
E-mail: [email protected]

Received Date: October 30, 2015 Accepted Date: January 02, 2015 Published Date: January 10, 2015

Citation: Zhang W, Guo Z, Zhang J, Jiang J, Pan X (2016) Can We Control the Progression of HIV by Monitor Markers of Microbial Translocation?. J Antivir Antiretrovir 8:001-005. doi: 10.4172/jaa.1000127

Copyright: © 2015 Zhang W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



This review summarizes microbial translocation in HIV infection. Microbial translocation can be measured by bacterial products in plasma, such as LPS and bacterial DNA or RNA fragments, or indirectly by LBP, sCD14, EndoCAb, and antiflagellin antibodies. In some study, these markers had contrary results. May be microbial translocation is not the sole driver of HIV progression. Several lines of research indicated that a major contributor to immune activation and disease progression during HIV infection was microbial translocation. Although successful treatment with ART increased GALT CD4+ T cells and suppresses HIV RNA, the numbers of these cells did not return to prior levels. There is a negative effect of mucosal immune dysfunction and microbial translocation on HIV disease progression in the presence of ART. The topic of microbial translocation and immune activation in HIV infection still is a research focus.


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