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Journal of Molecular Biomarkers & Diagnosis
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Review Article

Can We Use MDDScore for the Identification of Comorbid Major Depressive Disorder (MDD) in Patients with Chronic Pain?

John AB1*, Linda MT1, Joseph Shurman2 and Forest ST3

1Ridge Diagnostic Laboratories, Research Triangle Park, USA

2Scripps Memorial Hospital, Pain Management, 9888 Genesee Avenue La Jolla, CA, USA

3Veract Intractable Pain Clinic, 336 S Glendora Ave, West Covina, CA, USA

*Corresponding Author:
John AB
Ridge Diagnostic Laboratories
Research Triangle Park, USA
Tel: 440-465-3392
E-mail: [email protected]

Received Date: December 09, 2016; Accepted Date: December 26, 2016; Published Date: December 28, 2016

Citation: John AB, Linda MT, Shurman J, Forest ST (2016) Can We Use MDDScore for the Identification of Comorbid Major Depressive Disorder (MDD) in Patients with Chronic Pain? J Mol Biomark Diagn 8:319. doi: 10.4172/2155-9929.1000319

Copyright: © 2016 John AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


The prevalence of patients with chronic pain who display depressive symptoms is quite high, with depression potentially an integral component of chronic pain. Since the current subjective clinical diagnostic systems were not designed to assess depression in patients with chronic pain, they fail to adequately capture the nature of mood states of these patients. It is difficult to apply these assessment tools to segregate unipolar depression (MDD) from the demoralization inherent in chronic pain states. MDDScore™, a multivariate biomarker blood test for depression, was used to determine if it was possible to identify biomarker patterns consistent with major depressive disorder in multiple chronic pain states. Three study groups were analyzed, and included: (i) patients (n=93) with centralized Chronic Intractable Pain (CIP), (ii) patients (n=20) with chronic pain of diverse origin from Scripps Pain Clinic (SPC) and (iii) prospectively collected patients (n=28) with comorbid arthritis and depressive symptoms. A very distinct bimodal pattern was observed. Forty-nine of 93 CIP patients (52.7%), 18 of 28 (64.2%) of the arthritis patients, and 9 of 20 (45%) patients with chronic pain of diverse origin from Scripps Pain Clinic had MDDScores of ≥5. Thus, the biomarker panel could segregate patients into two major groups based upon MDDScores. These data suggest but not prove we can objectively identify chronic pain patients with a higher probability of comorbid major depression.

Importantly, we can use the biomarkers on the MDDScore panel to gain insight into and gauge the residual (post-treatment) level of inflammation in these intensively treated patients. To this end, we determined and compared the serum concentrations of alpha-1 antitrypsin (A1AT), Myeloperoxidase (MPO) and soluble tumor necrosis factor receptor type 2 (sTNFR2) in each of the patient populations studied.


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