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Cancer Metabolism and Its Therapeutic Implications | OMICS International | Abstract
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Review Article

Cancer Metabolism and Its Therapeutic Implications

Weiqin Lu1*, Craig D Logsdon2 and James L Abbruzzese1*
1Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
2Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Corresponding Authors : Weiqin Lu
Department of Gastrointestinal Medical Oncology
The University of Texas M.D. Anderson Cancer Center
Box 0426, 1515 Holcombe Boulevard
Houston, TX 77030, USA
Tel: (713)745-2093 or (713)792-2828
Fax: (713)404-3333
E-mail:[email protected]
  James L Abbruzzese
Department of Gastrointestinal Medical Oncology
The University of Texas M.D. Anderson Cancer Center
Box 0426, 1515 Holcombe Boulevard
Houston, TX 77030, USA
Tel: (713)745-2093 or (713)792-2828
Fax: (713)404-3333
E-mail: [email protected]
Received July 18, 2013; Accepted August 30, 2013; Published September 03, 2013
Citation: Lu W, Logsdon CD, Abbruzzese JL (2013) Cancer Metabolism and Its Therapeutic Implications. J Cell Sci Ther 4:143. doi: 10.4172/2157-7013.1000143
Copyright: © 2013 Lu W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The goal of cancer therapy is to selectively kill cancer cells without significant adverse toxicity to normal cells. Tremendous progress has been made to understand the molecular mechanisms of cancer and we have realized that cancer cells have remarkable heterogeneity and adaptability, making them difficult to be targeted therapeutically. With the advanced developments in molecular biology and high throughput ‘omics’ technologies, metabolic alteration is revealed as the common feature of human cancer. The activation of oncogenes and/or inactivation of tumor suppressors are found to be important metabolic switch regulators. Some metabolic enzymes in cancer have gained non-enzymatic functions to facilitate tumor growth and adaptation. Metabolic reprogramming of cancer cells not only promotes survival and proliferation but also tolerates stress and induces drug resistance. Therefore, cancer metabolism might be a novel target for cancer therapy. This article reviews current understanding of cancer metabolism with major focus on glucose and glutamine metabolisms and their potential therapeutic implications.

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