alexa Cancer Stem Cell and Gastrointestinal Cancer: Current S
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Review Article

Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications

Rizwan Ahmad1, Punita Dhawan1-3 and Amar B Singh1-3*
1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, USA
2Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA
3VA Nebraska- Western Iowa Health Care System, Omaha, NE, USA
Corresponding Author : Amar B Singh
Associate Professor
Department of Biochemistry and Molecular Biology Member
Fred and Pamela Buffett Cancer Center
University of Nebraska Medical Center 985870
Omaha, NE 68198-5870, USA
Tel: 402-559-6340; 402-559-8811
E-mail: [email protected]
Received: January 18, 2016; Accepted: February 19, 2016; Published: February 26, 2016
Citation: Ahmad R, Dhawan P, Singh AB (2016) Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications. Biochem Pharmacol (Los Angel) 5:202. doi:10.4172/2167-0501.1000202
Copyright: © 2016 Ahmad R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

The cancer stem cells (CSCs) are biologically distinct subset of rare cancer cells with inherent ability of self-renewal, de-differentiation, and capacity to initiate and maintain malignant tumor growth. Studies have further reported that CSCs prime cancer recurrence and therapy resistance. Therefore, targeting CSCs to inhibit cancer progression has become an attractive anti-cancer therapeutical strategy. Recent technical advances have provided a greater appreciation of the multistep nature of the oncogenesis and also clarified that CSC concept is not universally applicable. Irrespective, the role of the CSCs in gastrointestinal (GI) cancers, responsible for the most cancer-associated death, has been widely accepted and appreciated. However, despite the tremendous progress made in the last decade in developing markers to identify CSCs, and assays to assess tumorigenic function of CSCs, it remains an area of active investigation. In current article, we review findings related to the role and identification of CSCs in GI-cancers and discuss the crucial pathways involved in regulating CSCs populations’ development and drug resistance, and use of the tumoroid culture to test novel CSCs-targeted cancer therapies.

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