Cancer Stem Cells - Therapeutic Boon!
Department of Oral Medicine and Radiology, Krishnadevaraya dental college and hospital, India
- *Corresponding Author:
- Dr. Shrihari TG, PhD
Department of Oral Medicine & Radiology
Krishnadevaraya dental college and hospital
Bangalore -562157, Karnataka, India
E-mail: [email protected]
Received Date: June 15, 2011; Accepted Date: September 27, 2011; Published Date: September 29, 2011
Citation: Shrihari TG (2011) Cancer Stem Cells - Therapeutic Boon! J Cancer Sci Ther 3:197-200. doi: 10.4172/1948-5956.1000088
Copyright: © 2011 Shrihari TG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cancer stem cells (CSC) are recently proposed to be the cancer initiating cells responsible for tumorigenesis and contribute to cancer resistance. Like normal stem cells, cancer stem cells should be rare, quiescent and capable of self renewing & maintaining tumor growth and heterogeneity. Although the concept of cancer stem cells originates from that of normal stem cells, cancer stem cells are not necessarily aberrant counterparts of normal stem cells. In fact, they may arise from stem cells or committed progenitors of corresponding tissues & even cells from other tissues. At the molecular level, the alteration of stem cell self-renewal pathways has been recognized as an essential step for cancer stem cells transformation. Better understanding of cancer stem cell will no doubt lead to new era of both basic & clinical research, reclassification of human tumors & development of novel therapeutic strategies specifically targeting cancer stem cells.