alexa Cancer-Associated-Fibroblast Induces Epithelial-Mesench
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Research Article

Cancer-Associated-Fibroblast Induces Epithelial-Mesenchymal Transition of Gastric Cancer Cells via Activating Thy-1

Weiguo Hu1,2#, Chao Li1,2#, Jing Sun1,2, Bo Feng1,2, Daohai Zhang3, Junjun Ma1,2, Lu Zang1,2, Hongchao Zhao1,2, Weiguo Xu1,2, Binya Liu4, Minhua Zheng1,2*# and Zhenggang Zhu1,2*
1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , P. R. China
2Shanghai Minimally Invasive Surgery Center, Shanghai, P. R. China
3Cancer Research Group, The Canberra Hospital, and ANU Medical School, The Australia National University, Garran , ACT, Australia
4Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , P. R. China
#Contributed equally as co-first authors.
Corresponding Authors : Zhenggang Zhu
Department of General Surgery, Ruijin Hospital
Shanghai Jiao Tong University School of Medicine
Shanghai 200025, P. R. China
Tel: +86-21-64458887
Fax: +86-21-64458887
E-mail: [email protected]
  Minhua Zheng
Department of General Surgery, Ruijin Hospital
Shanghai Jiao Tong University School of Medicine
Shanghai 200025, P. R. China
Tel: +86-21-64458887
Fax: +86-21-64458887
E-mail: [email protected]
Received August 28, 2014; Accepted September 22, 2014; Published September 26, 2014
Citation: Hu W, Li C, Sun J, Feng B, Zhang D, et al. (2014) Cancer-Associated- Fibroblast Induces Epithelial-Mesenchymal Transition of Gastric Cancer Cells via Activating Thy-1. J Carcinog Mutagen 5:190. doi: 10.4172/2157-2518.1000190
Copyright: © 2014 Hu W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Cancer-associated fibroblasts (CAFs) are the key stromal cells in solid tumor microenvironment and are crucial for facilitating tumor metastasis. However, the detailed mechanism of how CAFs induce metastasis in human gastric cancer remains to be elucidated. In this study, using the CAFs isolated from human gastric tumor tissues, we have demonstrated that co-culturing of the CAFs with gastric cancer cells could activate the epithelial-mesenchymal transition (EMT) program, leading to enhanced cancer cell migration and invasion. In the CAF cells, Thy-1 expression was significantly increased, compared to the normal fibroblasts. Mechanistic studies revealed that depletion of Thy- 1 by siRNA in CAF cells attenuated the CAFs-induced EMT and aggressiveness in gastric cancer cells. Taken together, our studies indicate a significant role of Thy-1 in CAFs-induced gastric cancer progression. Targeting Thy-1 could be a potential therapeutic strategy for gastric cancer treatment.

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