alexa Canceromics and P3 medicine | OMICS International | Abstract
ISSN: 2376-0311

JBR Journal of Clinical Diagnosis and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Editorial

Canceromics and P3 medicine

Ashutosh Halder*

Department of Reproductive Biology, AIIMS, Delhi, India

Corresponding Author:
Ashutosh Halder
Department of Reproductive Biology
AIIMS, New Delhi, India
Tel: 91-11-26594211
E-mail: [email protected]

Received Date: November 22, 2014; Accepted Date: November 22, 2014; Published Date: November 29, 2014

Citation: Halder A (2015) Canceromics and P3 medicine. J Clin Diagn Res 3:e104. doi:10.41722376-0311.1000e104

Copyright: © 2014 Halder A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cancer is a disease of the genome. The first evidence for the role of genetics in cancer causation was identification of Philadelphia chromosome in chronic myeloid leukaemia [1] and now we are in such a state that we can create neoplastic cells in the laboratory through genetic manipulation of normal cells. Normal cells can be transformed into cancer cells by introducing few genes (hTERT, Ras, large T oncoprotein of simian virus 40, etc.) in embryonic cells or telomerase negative cells [2]. De novo neoplastic transformation is initiated by a genetic lesion due to an error occurring during normal cell division. This initial event provides a platform for other genetic lesions to develop in due course of time. When the proper combination of genetic lesions accumulates in cell, it becomes malignant. Neoplastic cells possess numerous chromosomal (aneuploidy, polyploidy, rearrangements, deletions, amplifications, etc.) and/or genomic (mutations, small deletions and small insertions) and/or epigenomic (promoter/euchromatin permethylation, heterochromatin deacetylation, miRNA, etc.) alterations. This genomic changes are multi steps process and mainly due to failure in check points of cell cycle regulation. Genomic and epigenomic abnormalities are more with alignant and metastatic tumors than benign tumors. The hallmark of cancer cells are genetic instability, self-maintained replication, neo-angiogenesis, invasion and metastasis and longer survival. Furthermore, every cancer patient is different, every tumor is different, every tumor cells with 100s of genomic/ epigenomic abnormalities (more with lung cancers, melanomas, etc.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version