Canine Mammary Osteosarcomas
Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden
- *Corresponding Author:
- Eva Hellmen
Department of Anatomy
Physiology and Biochemistry
Swedish University of Agricultural Sciences
Tel: +46 18 672128
E-mail: [email protected]
Received date: January 09, 2013; Accepted date: February 28, 2014; Published date: March 03, 2014
Citation: Hellmen E (2014) Canine Mammary Osteosarcomas. J Veterinar Sci Technol 5:163. doi:10.4172/2157-7579.1000163
Copyright: © 2014 Hellmen E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
This article describes five representative cases of canine mammary osteosarcomas and induced tumours by a cloned canine mammary osteosarcoma cell line in nude mice. All five primary tumours were combined mammary osteosarcomas i.e. composed of both cartilage and bone tissues. In four of the five cases the metastases were also combined osteosarcomas. However, for the metastases in one dog and in the nude mice, only bone forming and spindle cell tumours were seen. The metastases were spread directly to the lungs by the blood in three dogs, and via the lymph nodes in two dogs. The metastases differed in morphology, both within and between different metastatic sites. Some of the metastases had an even lower grade than the corresponding primary tumour.