alexa Cannabinoids and the Urinary Bladder | OMICS International
ISSN: 2161-0932

Gynecology & Obstetrics
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Review Article

Cannabinoids and the Urinary Bladder

Evangelia Bakali1,2* and Douglas G Tincello1,2

1University Hospitals of Leicester, NHS trust, Leicester, UK

2Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK

*Corresponding Author:
Dr. Evangelia Bakali
Reproductive Sciences Section
Department of Cancer Studies and Molecular Medicine
University of Leicester
Robert Kilpatrick Clinical Sciences Building
P.O. Box 65, Leicester LE2 7LX, UK
Tel: +44 116 252 3165
E-mail: [email protected]

Received Date: July 17, 2013; Accepted Date: August 13, 2013; Published Date: August 16, 2013

Citation: Bakali E, Tincello DG (2013) Cannabinoids and the Urinary Bladder. Gynecol Obstet 3:163. doi: 10.4172/2161-0932.1000163

Abstract

The presence of the Endocannabinoid System (ECS) in the urinary bladder has led to speculation that endocannabinoid-signalling is involved in the signal transduction pathways regulating bladder relaxation and may be involved in pathophysiological processes of the bladder. On the basis of this evidence, it was postulated that the binding of endocannabinoids to the cannabinoid receptors (CB1 and CB2) may result in relaxation of the urinary bladder during the filling phase. Dysregulation of the ECS in human bladder may be responsible for the aetiopathogenesis of Overactive Bladder Syndrome (OAB) and Detrusor Overactivity (DO).

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