alexa Carbaryl, A Pesticide Causes “Reproductive Toxicity” in Albino Rats
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Carbaryl, A Pesticide Causes “Reproductive Toxicity” in Albino Rats

Sajad Hamid1*, Seema Sharm2 and Shayama Razdan2

1Lecturer Anatomy, SKIMS Medical College, Jammu & Kashmir, India

2Professor Anatomy, Government Medical College, Jammu, Jammu & Kashmir, India

*Corresponding Author:
Sajad Hamid
Lecturer Anatomy, SKIMS Medical College
Bemina, Srinagar, Jammu & Kashmir, India
Tel: 9419506978
E-mail: [email protected]

Received date: August 08, 2012; Accepted date: August 31, 2012; Published date: September 03, 2012

Citation: Hamid S, Sharm S, Razdan S (2012) Carbaryl, A Pesticide Causes “Reproductive Toxicity” in Albino Rats. J Clin Exp Pathol 2:126. doi:10.4172/2161-0681.1000126

Copyright: © 2012 Hamid S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The key to man’s health lies largely in his environment & often man is responsible for the pollution of his environment through urbanization, industrialization and other human activities for example commercial agriculture and garden pest control etc. by using pesticides. Pesticides, though present in the environment in small quantities as compared to other contaminants such as industrial wastes and fertilizers, account for public and scientific concern due to their high biological activity. In the recent years, use of carbamate insecticides has gained importance due to ban of the insecticides belonging to Organochlorine groups that is D.D.T., Aldrin, Lindane and Endosulfan. These pesticides have a tendency to persist and have potential to bioaccumulate in the body Kamrin [1]. Concern about the susceptibility of the male reproductive system to drugs or environmental agents has assumed an increasing extent. The outcome of such exposures have included not only reduced fertility but also embryo/fetal loss, birth defects, childhood cancer, and other postnatal or functional deficits. Carbaryl is one of the most important insecticides as it is widely produced and used which has prompted us to initiate this study . The present study was conducted on 40 male Wistar albino rats as experimental animals. The rats were procured from the Animals House of the Department of Pharmacology, Government Medical College, Jammu. The rats were divided in four groups as normal control group I, group II, group III and group IV. All the rats were group housed and were fed with standard pellet diet and water for two weeks. After two weeks, the rats of group I were left as such and rats of groups II, III and IV were given 50 mg, 100 mg and 200 mg/kg body weight/day of carbaryl drug in 0.2 ml of groundnut oil orally, 6 days/week for 60 days, respectively. After 60 days, all the rats were anaesthetized by keeping them in an inverted glass jar containing large piece of cotton soaked in anaesthetic ether. The testis were dissected out from each rat and were cut into smaller pieces. These pieces were immediately fixed in 10% formalin. The blocks were prepared for section cutting with a microtome by paraffin wax embedding method. The sections of 7 μ thickness were mounted on glass slides and were stained by H&E and Masson’s trichome stain. The following findings are drawn from the study:- (1) There is variation in the shape of seminiferous tubules of testis. (2) There is sloughing of the germinal cells from the basement membrane. (3) There is depressed spermatogenesis and loss of sperms. (4) Some tubules are showing accumulation of cellular masses in the lumen of seminiferous tubules of testis. (5) Interstitial spaces are showing the oedema. (6) Degenerated Leydig cells are also seen. These findings are highly conclusive of reproductive toxicity produced by an insecticide, Carbaryl. It is concluded that the toxic effects are more pronounced in the peripheral parts of the sections of testis. Moreover, intensity of toxic effects both in peripheral and central parts increases with increase in dosage of the carbaryl drug.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords