Cardiac Depressant Activity of Erythrina variegata Linn on Isolated Frog-HeartKarthikeyan R* and Koushik OS
Department of Pharmacognosy, Vignan Pharmacy College, Vadlamudi-522213, AP, India
- *Corresponding Author:
- R Karthikeyan
Department of Pharmacognosy, Vignan Pharmacy College
Vadlamudi 522213, AP, India
E-mail: [email protected]
Received date: September 18, 2015; Accepted date: October 12, 2015; Published date: October 15, 2015
Citation: Karthikeyan R, Koushik OS (2015) Cardiac Depressant Activity of Erythrina variegata Linn on Isolated Frog-Heart. J Pharmacogn Nat Prod 1:107. doi: 10.4172/2472-0992.1000107
Copyright: © 2015 Karthikeyan R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Erythrina variegata Linn of the family leguminaceae is a medium sized deciduous small tree with prickly stems and branches, leaves with triangular leaflets and large coral red flowers and grows all over Bangladesh. Different parts of E. variegata have used in traditional medicine as nervine sedative, febrifuge, anti-asthmatic and antiepileptics.It is having the d-tubacurarine like activity. The present study was under taken to evaluate the cardiac depressant activity of Erythrina variegata in experimental animal model.
Materials and method: Aqueous extract of E. variegata was tested for cardiac depressant action by using frog isolated heart model. Different concentration of atropine sulphate is used along with plant water extract.
Results: The water extract shows the significant cardiac depressant activity.
Conclusion: The present study shows that E. variegata has significant cardiac depressant activity.