alexa Cardiac Failure Caused by the Association of Carboplatin and Gme citabine Chemotherapy in a Patient with Metastatic Urothelial Cancer: AC ase Report | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Cardiac Failure Caused by the Association of Carboplatin and Gme citabine Chemotherapy in a Patient with Metastatic Urothelial Cancer: AC ase Report

Tiong FL1*, Cornillet L2 and Houede N1
1Oncology Unit, University of Nimes, France
2Cardiology Unit, University of Nimes, France
Corresponding Author : Florence Lai Tiong
Oncology unit, University of Nimes, France
Tel: +33 825 31 41 16
E-mail: [email protected]
Received: November 09, 2015; Accepted:December 02, 2015; Published: December 09, 2015
Citation: Tiong FL, Cornillet L, Houede N (2015) Cardiac Failure Caused by the Association of Carboplatin and Gemcitabine Chemotherapy in a Patient with Metastatic Urothelial Cancer: A Case Report. J Clin Case Rep 5:670. doi:10.4172/2165-7920.1000670
Copyright: © 2015 Tiong FL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Introduction: Carboplatin is one of the most frequently drug, used in the treatment of many cancers. Several agents are known to cause cardiomyopathy and myocardial ischemia such as Anthracyclines and Fluorouracil. Descriptions of cardiac events associated with platinum agents are less common. Case Report: We report the case of a seventy-seven year-old man, who had no cardiovascular comorbidity. He was treated with Carboplatin and Gemcitabine infusions for a metastatic urothelial cancer. He presented a heart failure after blood infusion two weeks after the end of chemotherapy. Discussion: A few cases of cardiovascular toxicity due to Carboplatin have been reported immediately during the treatment or some weeks later. The increased oxidative stress could be one of the mechanisms. Conclusion: More studies are needed to evaluate the prevalence of these toxicities and to guide practicioners in decision making.

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