alexa Cardiac Progenitor Cells and their Therapeutic Applicat
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair

Lukas Cyganek1,2, Simin Chen1,2, Thomas Borchert1,2 and Kaomei Guan1,2*
1Department of Cardiology and Pneumology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany
2DZHK (German Center for Cardiovascular Research), Partner site Gottingen, Germany
Corresponding Author : Kaomei Guan, PhD
Department of Cardiology and Pneumology
University Medical Center Göttingen
Robert-Koch-Str. 40, 37075 Gottingen, Germany
Tel: 0049-(0)551-395321
Fax: 0049-(0)551-398124
E-mail: [email protected]
Received: April 15, 2013; Accepted: June 03, 2013; Published: June 07, 2013
Citation: Cyganek L, Chen S, Borchert T, Guan K (2013) Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair. J Clin Exp Cardiolog S11:008. doi: 10.4172/2155-9880.S11-008
Copyright: © 2013 Cyganek L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google


Heart disease is the principal cause of death in humans. Stem cell-based therapy for heart regeneration has long been seen as a potential application since the heart lacks adequate intrinsic regenerative potential. In the cardiovascular field, clinical trials have already been carried out by implantation of both bone marrow-derived stem cells and cardiac resident progenitor cells derived from the adult heart tissue into the injured myocardium to restore the functionality of the heart after damage. However, before a robust stem and progenitor cell-based therapy for cardiovascular diseases can be applied in the clinical setting, more research is necessary to generate sufficient quantities of functional cardiomyocytes from stem cells and to understand behavior of cardiomyocytes upon transplantation. A comprehensive understanding of the developmental processes involved in cardiogenesis might support further investigations in more efficient cell-based regeneration therapies. This review discusses the molecular aspects of cardiogenesis during early development and links the insights with the in vitro generation of cardiac progenitor cells as well as functional cardiomyocytes. Furthermore, we discuss the advantages of cardiac progenitor cells and cardiomyocytes derived from pluripotent stem cells and cardiac resident stem cells in the heart in regenerative applications to cope with the damaged heart.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version