alexa Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
Open Access

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Review Article

Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair

Lukas Cyganek1,2, Simin Chen1,2, Thomas Borchert1,2 and Kaomei Guan1,2*
1Department of Cardiology and Pneumology, University Medical Center Gottingen, Robert-Koch-Str. 40, 37075 Gottingen, Germany
2DZHK (German Center for Cardiovascular Research), Partner site Gottingen, Germany
Corresponding Author : Kaomei Guan, PhD
Department of Cardiology and Pneumology
University Medical Center Göttingen
Robert-Koch-Str. 40, 37075 Gottingen, Germany
Tel: 0049-(0)551-395321
Fax: 0049-(0)551-398124
E-mail: [email protected]
Received: April 15, 2013; Accepted: June 03, 2013; Published: June 07, 2013
Citation: Cyganek L, Chen S, Borchert T, Guan K (2013) Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair. J Clin Exp Cardiolog S11:008. doi: 10.4172/2155-9880.S11-008
Copyright: © 2013 Cyganek L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Heart disease is the principal cause of death in humans. Stem cell-based therapy for heart regeneration has long been seen as a potential application since the heart lacks adequate intrinsic regenerative potential. In the cardiovascular field, clinical trials have already been carried out by implantation of both bone marrow-derived stem cells and cardiac resident progenitor cells derived from the adult heart tissue into the injured myocardium to restore the functionality of the heart after damage. However, before a robust stem and progenitor cell-based therapy for cardiovascular diseases can be applied in the clinical setting, more research is necessary to generate sufficient quantities of functional cardiomyocytes from stem cells and to understand behavior of cardiomyocytes upon transplantation. A comprehensive understanding of the developmental processes involved in cardiogenesis might support further investigations in more efficient cell-based regeneration therapies. This review discusses the molecular aspects of cardiogenesis during early development and links the insights with the in vitro generation of cardiac progenitor cells as well as functional cardiomyocytes. Furthermore, we discuss the advantages of cardiac progenitor cells and cardiomyocytes derived from pluripotent stem cells and cardiac resident stem cells in the heart in regenerative applications to cope with the damaged heart.

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