Cardiac Resident Stem Cells: Work (Still) in ProgressAntonio Paolo Beltrami1,2, Daniela Cesselli1,2,3* and Carlo Alberto Beltrami1,2,3
- *Corresponding Author:
- Daniela Cesselli
Azienda Ospedaliero-Universitaria di Udine Pad.13, Piazzale S.Maria della Misericordia 15
33100 Udine, Italy
E-mail: [email protected]
Received date May 04, 2012; Accepted date June 15, 2012; Published date June 17, 2012
Citation: Beltrami AP, Cesselli D, Beltrami CA (2012) Cardiac Resident Stem Cells: Work (Still) in Progress. J Stem Cell Res Ther S9:001. doi:10.4172/2157-7633.S9-001
Copyright: © 2012 Beltrami AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nine years after the existence of resident Cardiac Stem Cells was first demonstrated, and despite the fact that we are right now evaluating the preliminary and promising results of the first phase I clinical trials, our understanding of the mechanisms responsible for cardiac regeneration is still partial and the ability to take advantage of it for therapeutic purposes can be considered still rudimentary. However, the worldwide urgency of developing new regenerative therapeutic strategies to reverse the progression of advanced heart failure is funneling a multidisciplinary effort aimed at better comprehending the biological pathways governing cardiac regeneration.
Therefore, in this paper we are critically reviewing the novel scientific evidences regarding: the multiplicity of stem cell populations hosted in the heart; the mechanisms regulating the cardiac embryonic development, such as the epithelial to mesenchymal transition, that may play a part in pathology too; the instructive micro-environmental factors acting within the Cardiac Stem Cell niche and the information gained from clinical trials. Hopefully the consideration of all these aspects will yield potential new targets and more effective strategies for cardiovascular regenerative therapies.