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  • Case Report   
  • Oncology and cancer case reports 2018, Vol 4(1): 141
  • DOI: 10.4172/2471-8556.1000141

Cardiogenic Shock 14 Years Post Anthracyclines

Stephanie Schmidt1*, Nils H Thoennissen2, Meike Rybczynski1, Florian M Wagner3, Ulrich M Gross4, Tobias Deuse5, Stefan Blankenberg1, Hermann Reichenspurner3 and Markus J Barten3
1Department of General and Interventional Cardiology, University Heart Center Hamburg, , Martinistrasse 52, D-20246 Hamburg, Germany
2Department of Oncology, Private Clinic Kloster Paradiese, , Im Stiftsfeld 1, D-59494 Soest-Paradiese, Germany
3Department of Cardiovascular Surgery, University Heart Center Hamburg, , Martinistrasse 52, D-20246 Hamburg, Germany
4Institute of Cardiac Diagnostic and Therapy GmbH (IKDT), , Moltkestrasse 31, D-12203 Berlin, Germany
5Department of Adult Cardiothoracic Surgery, University of California-San Francisco, , San Francisco, California, USA
*Corresponding Author : Stephanie Schmidt, Department of General and Interventional Cardiology, University of Texas , Martinistrasse 52, D-20246 Hamburg, Germany, Tel: +4940741052471, Email: [email protected]

Received Date: Nov 11, 2017 / Accepted Date: Feb 02, 2018 / Published Date: Feb 06, 2018


Significant advances in cancer treatment markedly improved survival rates of children diagnosed with cancer. However, chemotherapeutic or radiologic treatments might result in health consequences. For example, anthracycline agents were one of the most widely used chemotherapeutic drugs and known to cause cardiotoxicity.

We report on a 20-year old man with sudden onset of multi-organ-failure caused by a severe cardiogenic shock and the urgent need for implantation of a continuous-flow left ventricular assist device. Fourteen years before, he was diagnosed with childhood T-lymphocyte acute lymphoblastic leukaemia implying the application of the ALL-BFM-2000- protocol with a cumulative dose of 240 mg/m2 of anthracycline (120 mg/m2 daunorubicin + 120 mg/m2 doxorubicin). Postchemotherapeutic clinical monitoring lasted for two years till complete remission of leukaemia was diagnosed. Histology of intraoperatively taken endomyocardial biopsies showed an extensive fibrosis and vacuolated cardiomyocytes compatible with late-onset of anthracycline-induced cardiomyopathy. The patient recovered quickly and was discharged to rehabilitation 20 days after continuous-flow left ventricular assist device implant. Our case emphasized the need for consistent and detailed follow-ups to assess the global risk of premature cardiovascular disease prior to the development of congestive heart failure in cancer survivors of the childhood.

Keywords: Anthracycline; T-Lymphocyte Acute Lymphoblastic Leukaemia (T-ALL); Cardiomyopathy; Cardiogenic shock; Left ventricular assist device

Citation: Schmidt S, Blankenberg S, Rybczynski M, Thoennissen NH, Reichenspurner H, et al. (2018) A Rare Case Report in Maxillary Sinus with Weber-Ferguson Approach. Oncol Cancer Case Rep 4: 141. Doi: 10.4172/2471-8556.1000141

Copyright: © 2018 Schmidt S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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