Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury
- *Corresponding Author:
- Junhui Sun
Systems Biology Center
National Heart Lung and Blood Institute
National Institutes of Health
10 Center Drive, Bldg10/Rm8N206
Bethesda, MD 20892, USA
E-mail: [email protected]
Received Date: August 20, 2013; Accepted Date: September 13, 2013; Published Date: September 16, 2013
Citation: Sun J, Nguyen T, Kohr MJ, Menazza S, Murphy E (2013) Cardioprotective Role of Caveolae in Ischemia-Reperfusion Injury. Transl Med 3:114. doi: 10.4172/2161-1025.1000114
Copyright: © 2013 Sun J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Caveolae are flask-like invaginations of the plasma membrane enriched in cholesterol, sphingolipids, the marker protein caveolin and the coat protein cavin. In cardiomyocytes, multiple signaling molecules are concentrated and organized within the caveolae to mediate signaling transduction. Recent studies suggest that caveolae and caveolaeassociated signaling molecules play an important role in protecting the myocardium against ischemia-reperfusion injury. For example, cardiac-specific overexpression of caveolin-3 has been shown to lead to protection that mimics ischemic preconditioning, while the knockout of caveolin-3 abolished ischemic preconditioning. In this review, we discuss the molecular mechanisms and signaling pathways that are involved in caveolae-mediated cardioprotection, and examine the potential for caveolae as a therapeutic target for pharmaceutical intervention to treat cardiovascular disease.