alexa Cardiovascular Complications in Diabetes
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Review Article

Cardiovascular Complications in Diabetes

Roever L*, Casella-Filho A, Dourado PMM, Resende ES and Chagas ACP

Heart Institute (InCor), HCFMUSP- University of São Paulo Medical School, São Paulo, Brazil, Federal University of Uberlândia and Faculty of Medicine ABC, Santo André, Brazil

*Corresponding Author:
Leonardo S Roever-Borges
MHS, Laboratory of Vascular Biology
Heart Institute (InCor)
University of São Paulo Medical School
Av. Dr. Enéas de Carvalho Aguiar
44 05403-900 São Paulo Brazil
Tel: 55-11 30695259
Fax: 55-11 30695261
E-mail: [email protected]

Received date: May 10, 2014; Accepted date: August 12, 2014; Published date: August 20, 2014

Citation: Roever L, Casella-Filho A, Dourado PMM, Resende ES, Chagas ACP (2014) Cardiovascular Complications in Diabetes. J Diabetes Metab 5:415 doi: 10.4172/2155-6156.1000415

Copyright: © 2014 Roever L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Cardiovascular disease is the primary cause of morbidity and mortality among the diabetic population. Diabetic cardiomyopathy is characterized by early impairments in diastolic function, accompanied by the development of cardiomyocyte hypertrophy, myocardial fibrosis and cardiomyocyte apoptosis. The pathophysiology underlying diabetes-induced cardiac damage is complex and multifactorial, with elevated oxidative stress as a key contributor. The current evidence of molecular disturbances present in the diabetic heart, and their role in the development of diabetes-induced impairments in myocardial function and structure. This review aims to address the recent aspects of the relationships between diabetic cardiomyopathy and cardiovascular disease.

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