alexa Carnitine Palmitoyltransferase Inhibitor in Diabetes
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Carnitine Palmitoyltransferase Inhibitor in Diabetes

Chen Z1*, Cui F2, Meng L3, Chen G2, Li Z2, Xu Y4, Ma Z5 and Woldegiorgis G6

1Shanghai Chenlang Biotech LLC, Shanghai, China

2Shandong Binzhou People Hospital, Shandong, China

3Shengli Hospital, Shandong Dongying, China.

4Yantai Yuhuang-Ding Hospital, Shandong, China

5Dezhou People Hospital, Shandong, China

6Oregon Health and Science University, Bethesda, MD 20827, Beaverton, Portland, OR, USA

*Corresponding Author:
Dr. Zhan Chen
Shanghai Chenlang Biotech LLC, Shanghai, China
Tel: 4008805086
E-mail: [email protected]

Received Date: December 02, 2016; Accepted Date: December 30, 2016; Published Date: December 30, 2016

Citation: Chen Z, Cui F, Meng L, Chen G, Li Z, et al. (2016) Carnitine Palmitoyltransferase Inhibitor in Diabetes. J Mol Genet Med 10: 238 doi:10.4172/1747- 0862.1000238

Copyright: © 2016 Chen Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

This review addresses progress of carnitine palmitoyltransferase targeted pharmaceuticals in diabetes and the challenges ahead. Since the discovery of carnitine palmitoyltransferase (CPT), there are lots of publications on its role in disease. The wide tissue expression, functional and biological roles have documented the physiological importance of these enzymes both in health and disease. Thus, over the years, studies have revealed essential importance of CPT1 in mammalian pathophysiology revealing CPT1 as potential drug targets. Starting from a brief description of the main functional features of CPTs, their roles in physiology and pathophysiology of different human diseases, this review describes the main classes of small molecules which are able to regulate CPT1 for diagnostic and therapeutic applications.

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