alexa CAR-T: The Current and the Future
ISSN: 2165-7092

Pancreatic Disorders & Therapy
Open Access

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CAR-T: The Current and the Future

Kunal Mishra, Shu-Feng Zhou and Jiazhi Sun*
Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, USA
Corresponding Author : Dept. of Pharmaceutical Sciences
College of Pharmacy
University of South Florida
12901 Bruce B. Downs Blvd, Tampa
FL 33612, USA
Tel: +813-974-7468
Fax: 813-905-9885
E-mail: [email protected]
Received March 31, 2015; Accepted April 20, 2015; Published April 22, 2015
Citation: Mishra K, Zhou S-F, Sun J (2015) CAR-T: The Current and the Future. Pancreat Disord Ther 5:154. doi:10.4172/2165-7092.1000154
Copyright: © 2015 Kunal Mishra, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
 

Abstract

Chimeric antigen receptors (CARs) are recombinant receptors that are expressed on autologous T-cells. CAR-T usage has grown in recent years as a way to combat hematological and solid tumors. The purpose of this review is to describe new studies on CAR-T treatment along with our lab’s ideas on potential uses and pitfalls that could be investigated. The usage of TREG and antiCLTA4 as means for regulating CAR-T will also be looked at along with OX40, CD137 and CD27 receptors as means for increasing the efficacy of the treatment overall. In addition the usage of iCasp9 as a ‘suicide switch’ for the CAR-T treatment and the potential for a 4th generation CAR will be touched upon. Then the review will lead into talks about how such a treatment could be of potential use in treating solid and hematological cancer.

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