Cartilage Oligomeric Matrix Protein as New Marker in Diagnosis of Rheumatoid Arthritis
|Mohamed I Aref1 and Hamdy Ahmed2*|
|1Clinical pathology Department, Al Azhar University, Cairo, Egypt|
|2Biochemistry of National Research Center (NRC), Al Azhar University, Egypt|
|Corresponding Author :||Hamdy A Ahmed
Biochemistry of National Research Center (NRC)
Al Azhar University, Cairo, Egypt
E-mail: [email protected]
|Received March 23, 2015; Accepted May 01, 2015; Published May 05, 2015|
|Citation: Aref MI, Ahmed H (2015) Cartilage Oligomeric Matrix Protein as New Marker in Diagnosis of Rheumatoid Arthritis. Mod Chem appl 3:151. doi: 10.4172/2329-6798.1000151|
|Copyright: © 2015 Aref MI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Rheumatoid arthritis (RA) is the most common systemic inflammatory autoimmune disease of unknown etiology. The early in diagnosis of RA is crucial. To facilitate diagnosis during the early stages of RA, when often not all clinical symptoms are manifest, a good serological marker is needed. Among serological markers are rheumatoid factor (RF), erythrocyte sedimentation rate (ESR) C-reactive protein (CRP), anti-cyclic citrullinated peptites (anti-CCP) and cartilage oligomeric matrix protein (COMP). A comparison between those markers in respect to the accuracy was the aim of this study.
Patient and methods: Sixty patients with RA and auto-immune non-RA were selected for this study compared with 20 normal healthy persons. The results showed both COMP and anti-CCP can be help for diagnostic value than other selected parameter.