alexa Cartilage Tissue Engineering; Lessons Learned From Peri
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Cartilage Tissue Engineering; Lessons Learned From Periosteum

Peter J Emans1*, Marjolein MJ Caron1, Lodewijk W van Rhijn1, V Prasad Shastri2 and Tim JM Welting1

1Department of Orthopaedic Surgery, Maastricht University Medical Center +, the Netherlands

2Institute for Macromolecular Chemistry, Hermann Staudinger Haus, University of Freiburg, Freiburg, Germany

Corresponding Author:
Peter J Emans
Department of Orthopaedic Surgery
Maastricht University Medical Center +
P.O. Box 58006202 AZ Maastricht the Netherlands
Tel: +31 -43-3877035
Fax: +31 -43-3874893
E-mail: [email protected]

Received date: August 01, 2011; Accepted date: November 05, 2011; Published date: November 07, 2011

Citation: Emans PJ, Caron MMJ, van Rhijn LW, Shastri VP, Welting TJM (2011) Cartilage Tissue Engineering; Lessons Learned From Periosteum. J Tissue Sci Eng S2:002. doi:10.4172/2157-7552.S2-002

Copyright: © 2011 Emans PJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Cartilage, due to its unique physiology (lack of vasculature), can be potentially repaired using tissue engineered in the laboratory, by combining cells and with a supporting scaffold. This requires a marriage between material science, cell biology, and translational medicine, a concept well established as Tissue Engineering. Over the years the in vivo and in vitro chondrogenic potential of periosteum has been recognised by many researchers and as such periosteum is explored both to repair cartilage defects directly by transplanting periosteum into the cartilage defect or by using periosteum as a cell source for cartilage engineering purposes. The initial example hereof is the first generation of Autologous Chondrocyte Transplantation. Graft hypertrophy and ossification remain the primary drawbacks of cartilage repair strategies using engineered cartilage. These drawbacks may (partially) be due to the endochondral ossification process that can take over when cartilage is repaired. In this process chondrogenesis of progenitor cells is followed by hypertrophy of these cells and subsequent ossification. Periosteal progenitor cells go through this process in order to heal bone fractures. This review provides an overview of the role of periosteum in cartilage repair and cartilage tissue engineering and illustrates how periosteum can be used as a model to study the endochondral process. Such studies may provide clues to further optimize cartilage tissue engineering by identifying important factors which are capable of maintaining cells in their chondrogenic phenotype. Finally, the use of periosteum to engineer cartilage in vivo at an extra-articular site is described.

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