Causal Inference in the Age of Decision MedicineYazdani A* and Boerwinkle E
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
- *Corresponding Author:
- Azam ‘Mandana‘ Yazdani
School of Public Health
University of Texas Health Science Center-Houston, USA
E-mail: [email protected]
Received Date: September 10, 2014; Accepted Date: October 07, 2014; Published Date: October 09, 2014
Citation: Yazdani A, Boerwinkle E (2014) Causal Inference in the Age of Decision Medicine. J Data Mining Genomics Proteomics 6:163. doi: 10.4172/2153-0602.1000163
Copyright: © 2015 Yazdani A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Causal analyses and causal inference is a growing area of biostatics. In parallel, there is increasing focus on using genomic information to guide medical practice, i.e. personalized medicine or decision medicine. This perspective discusses causal inference in the context of personalized or decision medicine, including the assumptions and the concept that the task is different depending on whether the primary goal is the average response of treatment in the population or the ability to characterize the response for an individual or a subgroup. This perspective provides a tutorial of modern causal inference and then provides suggestions how application of specific kinds of causal inference would promote advances in translational sciences. The concept of the subpopulation causal effect is one path toward improved decision medicine. A dataset containing cardiovascular disease risk factor levels and genomic information is analyzed and different causal effects are estimated.