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ISSN: 2168-975X

Brain Disorders & Therapy
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Review Article

Causes of Neurodegeneration in Diabetes: Possible Culprits and Therapeutic Targets

Uthra Rajamani*
University of California Davis Medical Center, 4635 2nd Avenue, Research I Building, Sacramento, CA, USA
Corresponding Author : Uthra Rajamani
University of California Davis Medical Center
4635 2nd Avenue, Research I Building
Sacramento, CA , 95817, USA
Tel: 916734 1316
Fax: 916734 6593
E-mail: [email protected]
Received May 25, 2014; Accepted June 02, 2014; Published June 16, 2014
Citation: Rajamani U (2014) Causes of Neurodegeneration in Diabetes: Possible Culprits and Therapeutic Targets. Brain Disord Ther 3:130. doi:10.4172/2168-975X.1000130
Copyright: © 2014 Rajamani U. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Diabetes, a global epidemic, has been shown to be linked to incidence of neurodegenerative disorders. Hyperglycemia is linked to cognitive decline, Alzheimer’s disease, dementia and neurodegeneration in general. The mechanisms of diabetes/hyperglycemia-mediated neurodegeneration are largely unknown. This review sheds light on mechanisms that could possibly lead to hyperglycemia-mediated neurodenegeration namely apoptosis, oxidative stress, AGE, etc. Additionally relevant therapeutic strategies are also discussed.

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