alexa CD200 Suppresses the Natural Killer Cells and Decreased its Activity in Acute Myeloid Leukemia Patients | OMICS International | Abstract
ISSN: 2329-6917

Journal of Leukemia
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Commentary

CD200 Suppresses the Natural Killer Cells and Decreased its Activity in Acute Myeloid Leukemia Patients

Maha Atfy1*, Hoda F. Ebian1, Sherren M. Elshorbagy2 and Heba H. Atteia3

1Department of Clinical Pathology, Hospitals of Zagazig University, Egypt

2Department of Hematology & Medical Oncology, Faculty of Medicine, Zagazig University, Egypt

3Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Egypt

*Corresponding Author:
Maha Atfy
MD, Clinical Pathology Departments, Hospitals of Zagazig University
Sharkeyia, Egypt, P.O.Box: 44519
Tel: +2 012 3834310
Fax: 2055 232 1510
Email: [email protected]

Received date: September 15, 2015; Accepted date: October 12, 2015; Published date: October 22, 2015

Citation: Atfy M, Ebian HF, Elshorbagy SE, Atteia HH (2015) CD200 Suppresses the Natural Killer Cells and Decreased its Activity in Acute Myeloid Leukemia Patients. J Leuk 3:190. doi:10.4172/2329-6917.1000190

Copyright: © 2015 Atfy M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Immunosuppression is greatly involved in tumor escape from immune surveillance in acute myeloid leukemia (AML) patients. Being an immunosuppressive molecule, CD200 is upregulated in some hematological malignancies. CD200 also represents an independent prognostic factor in AML. In the present study, we assessed the influence of CD200 expression level in AML cases by flow cytometry on natural killer (NK) cell activity and evaluate its prognostic implications. In this study it was reported that CD200high patients showed a reduction in the frequency of activated NK cells (CD56dim) compared with CD200low patients. Survival analysis showed that the patients with CD200High expression had significantly shorter OS (median, 18 months) than the patients with CD200Low expression (median, 25 months) (P = 0.0188) with hazard ratio of 0.4860 (95%CI: 0.2261–1.0447). Interferon-γ level was highly expressed in AML cases with CD200low when compared to CD200high (P>0.0001*). Generally, our findings suggest that CD200 overexpression suppresses NK cell antitumor response in AML patients and hence increased risk relapse in AML patients.

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