alexa CD8+ T Cells Are Compromised In Human Pancreatic Cancer
ISSN: 2161-1025

Translational Medicine
Open Access

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Research Article

CD8+ T Cells Are Compromised In Human Pancreatic Cancer

Xianjun Yu1*, Shunrong Ji1, Jin Xu1, Wantong Yao1, Bin Qu2, Wenwei Zhu1, Wenyan Xu1, Bo Zhang1 and Yongfeng Xu1

1Department of Pancreas and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China

2Institut für Biophysik, Universität des Saarlandes, Kirrberger Straße 8, Gebäude 58, 66421 Homburg, Saarland, Germany

*Corresponding Author:
Xianjun Yu
Professor and Chair
Department of Pancreatic & Hepatobiliary Surgery
Shanghai Cancer Center, Fudan University
No.270 DongAn Road, Shanghai, China
Tel: 021-64175590-1307
Fax: 021-64031446
E-mail: [email protected], or: [email protected]

Received Date: May 22, 2012; Accepted Date: June 08, 2012; Published Date: June 11, 2012

Citation: Yu X, Ji S, Xu J, Yao W, Qu B, et al. (2012) CD8+ T Cells Are Compromised In Human Pancreatic Cancer. Transl Med 2:105. doi:10.4172/2161-1025.1000105

Copyright: © 2012 Yu X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objectives and background: An efficient cellular immune response against cancer requires a robust population of CD8+ T cells with optimal cytotoxic functions. The aim of this study was to define the percentage of CD8+ T cells and the perforin expression level of the CD8+ T cells in the peripheral blood from patients with pancreatic adenocarcinoma. Methods: Fourty-six pancreatic cancer patients in our center between August 2011 and April 2012 were recruited. Thirty-five healthy persons were included as controls. Blood was drawn before surgery and one and a half months after surgery. Cells were labeled with monoclonal antibodies against perforin and surface antigen CD8 and were analyzed by flow cytometry. Results: Compared with the healthy controls, the percentage of CD8+ T cells was significantly decreased in pancreatic cancer patients. The level of perforin expression was also decreased in pancreatic cancer patients, whereas the percentage of CD8+ T cells was significantly increased after radical tumor resection. Conclusions: Both the number and function of CD8+ T cells were compromised in pancreatic cancer patients, which were partially recovered after the surgery.

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