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ISSN: 2157-7536

Journal of Steroids & Hormonal Science
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Review Article

Cell Models for the Study of Sex Steroid Hormone Neurobiology

Chang Su, Nataliya Rybalchenko, Derek A. Schreihofer, Meharvan Singh, Babak Abbassi and Rebecca L. Cunningham*

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107 USA

Corresponding Author:
Dr. Rebecca L. Cunningham
Ph.D, Department of Pharmacology and Neuroscience
University of North Texas Health Science Center at Fort Worth
3500 Camp Bowie Blvd
Fort Worth, TX 76107, USA
Tel: 817-735- 5080
Fax: 817-735-0408
E-mail: [email protected]

Received Date: September 06, 2011; Accepted Date: October 11, 2011; Published Date: October 15, 2011

Citation: Su C, Rybalchenko N, Schreihofer DA, Singh M, Abbassi B, et al. (2011) Cell Models for the Study of Sex Steroid Hormone Neurobiology. J Steroids Hormon Sci S2:003. doi: 10.4172/2157-7536.S2-003

Copyright: © 2011 Su C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 To date many aspects of neurons and glia biology remain elusive, due in part to the cellular and molecular complexity of the brain. In recent decades, cell models from different brain areas have been established and proven invaluable toward understanding this complexity. In the field of steroid hormone neurobiology, an important question is: what is the profile of steroid hormone receptor expression in these specific cell lines? Currently, a clear summary of such receptor profiling is lacking. For this reason, we summarized in this review the expression of estrogen, progesterone, and androgen receptors in several widely used cell lines (glial and neuronal) derived from the forebrain and midbrain, based on our own data and that from the literature. Such information will aid in the selection of specific cell lines used to test hypotheses related to the biology of estrogens, progestins, and/or androgens.

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