alexa Cellular Response of the Tendon Sheath in Tendon Injury: Experimental Research in New Zealand Rabbits | OMICS International | Abstract
ISSN: 2167-1222

Journal of Trauma & Treatment
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Special Issue Article

Cellular Response of the Tendon Sheath in Tendon Injury: Experimental Research in New Zealand Rabbits

Nick Sekouris1*, Athanasios Kefalas2, Konstantinos Soultanis3, Kalliopi Diamantopoulou4, Georgia Karagiannopoulou5, Panayotis Soucacos3 and Aristides Zoubos3
1Metropolitan’ General Hospital, Athens, Greece
2Hospital of Ioannina, Greece
3University of Athens, Medical School, ‘ATTIKON’ University Hospital, Haidari, Athens, Greece
4Department of Pathology, ‘RED CROSS’ General Hospital, Athens, Greece
5Department of Pathology, Medical School, ‘ARISTOTELIO’ University Hospital, U.T.H., Thessaloniki, Greece
*Corresponding Author : Nick Sekouris
Consultant Orthopeadic
‘Metropolitan’ General Hospital, Margaritas 25
Elliniko, 16777, Athens, Greece
Tel: 0030 6985010730
E-mail: [email protected]
Received September 17, 2013; Accepted October 17, 2013; Published October 21, 2013
Citation: Sekouris N, Kefalas A, Soultanis K, Diamantopoulou K, Karagiannopoulou G, et al. (2013) Cellular Response of the Tendon Sheath in Tendon Injury: Experimental Research in New Zealand Rabbits. J Trauma Treat S4:004. doi:10.4172/2167-1222.S4-004
Copyright: © 2013 Sekouris N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are are credited.

Abstract

Purpose: We aimed to investigate the synovial sheath cell migration in response to flexor tendon injury under direct visualization.

Methods: We used New Zealand rabbits based on an animal model described in previous studies, which we modified in order to create conditions similar to real tendon injury and healing. We used a special paint marker (1,1’-dioctadecyl1-3,3,3’,3’-tetramethylindocarbocyanine-percolate-Dil) of the sheath cells. The Flexor Digitorum Profondus first was sectioned through a distal skin incision and pulled outside the sheath through a proximal skin incision. Then the sheath was labeled. A second intrasynovial full thickness cross-section of the flexor was done and repaired by Kessler and running type suture. We harvested the tendons day 1, 3, 5, 7, 14 and 28 after tendon injury. Tendon sections were prepared with cryotomy and tested by infrared microscope. To evaluate our results, we divided the migration of synovial sheath cells in four phases: 1st phase) no or sporadic migration to the surface of the tendon, 2nd phase) massive migration to the surface of the tendon, 3rd phase) migration just below the surface of the tendon, and 4th phase) migration in the endotenon. For each day’s group the percentage of tendon sections in each phase of migration was determined.

Results: According to our findings the second phase of migration of cells was 85% reached on the 3rd day, the third phase 66.6% reached on the seventh day and the fourth phase 50% reached on the fourteenth day after flexor tendon injury.

Conclusions: This study confirms that the synovial sheath cells migrate first into the surface and later into the core of the healing tendon.

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