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ISSN: 2329-8847

Journal of Aging Science
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Review Article

Cellular Senescence by the Epigenetic Regulators Inhibitor of Growth

Thanakorn Pungsrinont and Aria Baniahmad*

Professor, Institute of Human Genetics, Jena University Hospital, Germany

*Corresponding Author:
Aria Baniahmad
Institute of Human Genetics, Jena University Hospital Kollegiengasse 10, 07743 Jena, Germany
Tel: +49-3641-935524
Fax: +49-3641-934706
E-mail: [email protected]

Received date: December 18, 2015; Accepted date: January 18, 2016; Published date: January 25, 2016

Citation: Pungsrinont T and Baniahmad A (2016) Cellular Senescence by the Epigenetic Regulators Inhibitor of Growth. Aging Sci 4:145. doi: 10.4172/2329-8847.1000145

Copyright: © 2015 Pungsrinont and Baniahmad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The epigenetic regulatory tumor suppressor, INhibitor of Growth 1 (ING1), obtained more focus since it has been suggested as one of the aging-related candidate genes among healthy elderly individuals. ING1 belongs to the ING family proteins characterized by a plant homeodomain (PHD), which is important for recognizing and binding to histone marks, thus allowing ING to regulate genes expression through histone modification and chromatin changes. Interestingly, the PHD of ING proteins is highly conserved among species between mammals, insects and plants. The ING factors regulate the program of cellular senescence and DNA repair, which are suggested to have a protective role in inhibiting cancer cells proliferation. Here, we provide an insight into the functional role of ING factors in development and tumor cells.

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