Ceragenins as Mimics of Endogenous Antimicrobial PeptidesMarjan M Hashemi1, Brett S Holden1, Bonita Durnaś2, Robert Bucki3 and Paul B Savage1*
- *Corresponding Author:
- Paul B Savage
Department of Chemistry and Biochemistry
Brigham Young University, C100 BNSN, Provo, USA
Tel: 1 801 422 4020
Fax: 1 801 422 0153
E-mail: [email protected]
Received date: April 18, 2017; Accepted date: May 10, 2017; Published date: May 17, 2017
Citation: Hashemi MM, Holden BS, Durnas B, Bucki R, Savage PB (2017) Ceragenins as Mimics of Endogenous Antimicrobial Peptides. J Antimicrob Agents 3:141. doi:10.4172/2472-1212.1000141
Copyright: © 2017 Hashemi MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ceragenins are small molecule mimics of endogenous antimicrobial peptides (AMPs), and as such display broadspectrum antimicrobial activity. These molecules are derived from a common bile acid and can be prepared at a large scale. Because ceragenins are not peptide based, they are not substrates for proteases. Gram-negative and positive bacteria are susceptible to ceragenins, including drug resistant organisms. Although ceragenins and colistin have common features, ceragenins retain full antibacterial activity against colistin-resistant Gram-negative bacteria. Bactericidal activity of ceragenins involves selective association with bacterial membranes followed by membrane depolarization. Due to this mechanism of action, which provides bactericidal activity against sessile bacteria, ceragenins eradicate established biofilms. Lipid-enveloped viruses (e.g. vaccinia) are deactivated by ceragenins, and topical application of a lead ceragenin decreases transmission of the virus in skin in a murine model. More recently, the activities of ceragenins against fungal pathogens have been reported, with minimum inhibition concentrations comparable to clinically used anti-fungal agents. In addition to antimicrobial activities, ceragenins have been shown to display some of the “secondary” activities attributed to AMPs. In vivo use of ceragenins to eradicate biofilms, prevent infection and accelerate bone growth demonstrate some of the types of applications in which ceragenins may be used to augment or replace activities of endogenous AMPs.