alexa Cervical Lymph Node Dissection in Papillary Thyroid Cancer: Pattern and Predictive Factors of Regional Lymph Node Metastas | OMICS International | Abstract
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Research Article

Cervical Lymph Node Dissection in Papillary Thyroid Cancer: Pattern and Predictive Factors of Regional Lymph Node Metastas

Guilherme Souza Silva*, Paulo Roberto Savassi Rocha, Jose Maria Porcaro Salles, Gustavo Meyer Moraes and Alexandre Andrade Sousa
UfMG, Belo Horizonte, MG Brazil
Corresponding Author : Guilherme Souza Silva
UfMG, Belo Horizonte, MG Brazil
Tel: +55 31 3409-5000
E-mail: [email protected]
Received February 01, 2014; Accepted March 25, 2014; Published March 27, 2014
Citation: Silva GS, Savassi Rocha PR, Porcaro Salles JM, Moraes GM, Sousa AA (2014) Cervical Lymph Node Dissection in Papillary Thyroid Cancer: Pattern and Predictive Factors of Regional Lymph Node Metastasis. Thyroid Disorders Ther 3:150. doi:10.4172/2167-7948.1000150
Copyright: © 2014 Silva GS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Papillary thyroid carcinoma (PTC) exhibits a high index of cervical lymphatic dissemination. Methods: Retrospective study of 101 cases of PTC subjected to total thyroidectomy associated with cervical lymph node dissection. Results: The incidence of neck metastasis was 50.5%, and all the metastases wereipsilateral to the primary tumor. Although the participants with metastases (N+) hadmore dissected lymph nodes than the group without metastases (p = 0.01), the lymphnode size was not a determinant of malignancy (p=0.34). Uni and multivariate analyses showed tumor size ≥ 1.0 cm, angiolymphatic invasion, and multicentric diseases were associated with lymphatic dissemination (p < 0.05). Conclusions: Factors predictive of cervical lymph node metastasis were tumor size ≥ 1.0cm, multicentric disease and angiolymphatic invasion. All the metastases wereipsilateral to the primary tumor. Lymph node size was not a reliable predictor of thepresence or absence of metastasis.

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