alexa Cervical Neoplasia-Cyto-Histological Correlation Bethes
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Research Article

Cervical Neoplasia-Cyto-Histological Correlation Bethesda System A Study of 276 Cases

Vaishali Jain* and AS Vyas

Associate Professor, Department of Pathology, Grant Medical College & Sir JJ group of hospitals, Byculla, Mumbai, India

*Corresponding Author:
Dr Vaishali Jain, MD
Associate Professor, Department of Pathology
Grant Medical College & Sir JJ group of hospitals
Byculla, Mumbai, India
E-mail: [email protected] com

Received date: October 07, 2010; Accepted date: November 23, 2010; Published date: November 25, 2010

Citation: Jain V, Vyas AS (2010) Cervical Neoplasia-Cyto-Histological Correlation (Bethesda System) A Study of 276 Cases. J Cytol Histol 1:106. doi: 10.4172/2157-7099.1000106

Copyright: © 2010 Jain V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Carcinoma uterine cervix is one of the leading causes of cancer death among women worldwide. To detect this widely prevalent cancer at an early stage, the simplest test has been a pap smear. Reporting of pap smears is done by using The Bethesda System 2001 prior to which many classification systems were developed [1,2,3,4]. To check the sensitivity and specificity of Bethesda system, the cytological findings have to be correlated with histology considering histopathology as gold standard. In our study, we have correlated cytological findings (pap smears) with corresponding histology after follow up of the symptomatic patients in the age range of 20 to 80 years. The main objectives were to study usefulness of cytology in detecting various preneoplastic and neoplastic lesions of cervix, to evaluate and to interpret the cases of epithelial lesions according to The Bethesda 2001 classification system [5] and correlation of cytological findings with follow-up histology sections. Analysis of different factors causing discrepancies was done. Aims: The study was conducted to study usefulness of cervical cytology by PAP smear and the application of the Bethesda 2001 system in classifying different preneoplastic and neoplastic lesions of cervix. Setting and design: With the use of PAP test and applying the BETHESDA 2001 classification 5, in the present study we have examined cervical smears of symptomatic patients in the age group ranging from 25 to 70 years. Inflammatory & unsatisfactory smears were excluded. The remaining cases showing epithelial abnormalities were followed up and biopsy slides were studied. Cytohistological correlation was done in those cases and results were obtained.


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