alexa Chalcone Scaffold based Antimycobacterial Agents | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Mini Review

Chalcone Scaffold based Antimycobacterial Agents

Fliur Macaev1*, Veaceslav Boldescu1,2, Serghei Pogrebnoi1 and Gheorghe Duca1

1Laboratory of Organic Synthesis, Institute of Chemistry of ASM, MD2028 Chisinau, Moldova

2Faculty of Chemistry and Chemical Technology, Moldova State University, MD2009 Chisinau, Moldova

*Corresponding Author:
Fliur Macaev
Laboratory of Organic Synthesis
Institute of Chemistry of ASM
Academiei str. 3, MD-2028 Chisinau, Moldova
Tel: +373 22 739754
Fax: 373 22 739954
E-mail: [email protected]

Received date: April 26, 2014; Accepted date: May 19, 2014; Published date: May 21, 2014

Citation: Macaev F, Boldescu V, Pogrebnoi S, Duca G (2014) Chalcone Scaffold based Antimycobacterial Agents. Med chem 4:487-493. doi:10.4172/2161-0444.1000183

Copyright: © 2014 Macaev F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This article represents a mini-review dedicated to chalcone derivatives with antimycobacterial activity. Natural and synthetic chlacones are reviewed. General and specific schemes of synthesis of chalchone derivatives are presented. QSAR and docking studies of certain chalcones are analyzed in respect of their antimycobacterial activity and inhibition of Mycobacterium tuberculosis enzymes.

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