alexa Challenges in Structural Investigation of Transient Protein-Protein Interactions | OMICS International | Abstract
ISSN: 2329-6798

Modern Chemistry & Applications
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Review Article

Challenges in Structural Investigation of Transient Protein-Protein Interactions

Kelly L Wormwood, Armand G Ngounou Wetie, Izabela Sokolowska, Alisa G Woods and Costel C Darie*
Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, USA
Corresponding Author : Costel C Darie
Biochemistry & Proteomics Group
Department of Chemistry & Biomolecular Science
Clarkson University, 8 Clarkson Avenue
Potsdam, NY, 13699-5810, USA
Tel: 315-268-7763
Fax: 315-268-6610
E-mail: [email protected]
Received November 29, 2013; Accepted January 22, 2014; Published January 24, 2014
Citation: Wormwood KL, Wetie AGN, Sokolowska I, Woods AG, Darie CC (2014) Challenges in Structural Investigation of Transient Protein-Protein Interactions. Mod Chem appl 2:117. doi:10.4172/2329-6798.1000117
Copyright: © 2014 Wormwood KL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Receptor Tyrosine Kinases (RTKs) are transmembrane proteins that, upon stimulation by their soluble ligands dimerize or multimerize and autophosphorylate themselves on the cytoplasmic side and activate signal transduction pathways, which in turn trigger either nuclear, transcriptional responses or a cellular effect such as cytoskeletal remodeling. However, while the classical RTK pathway is well understood, the intracellular protein interaction events that lead to these responses are still not yet well understood.

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