alexa Challenges in Structural Investigation of Transient Pro
ISSN: 2329-6798

Modern Chemistry & Applications
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Challenges in Structural Investigation of Transient Protein-Protein Interactions

Kelly L Wormwood, Armand G Ngounou Wetie, Izabela Sokolowska, Alisa G Woods and Costel C Darie*
Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, USA
Corresponding Author : Costel C Darie
Biochemistry & Proteomics Group
Department of Chemistry & Biomolecular Science
Clarkson University, 8 Clarkson Avenue
Potsdam, NY, 13699-5810, USA
Tel: 315-268-7763
Fax: 315-268-6610
E-mail: [email protected]
Received November 29, 2013; Accepted January 22, 2014; Published January 24, 2014
Citation: Wormwood KL, Wetie AGN, Sokolowska I, Woods AG, Darie CC (2014) Challenges in Structural Investigation of Transient Protein-Protein Interactions. Mod Chem appl 2:117. doi:10.4172/2329-6798.1000117
Copyright: © 2014 Wormwood KL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google


Receptor Tyrosine Kinases (RTKs) are transmembrane proteins that, upon stimulation by their soluble ligands dimerize or multimerize and autophosphorylate themselves on the cytoplasmic side and activate signal transduction pathways, which in turn trigger either nuclear, transcriptional responses or a cellular effect such as cytoskeletal remodeling. However, while the classical RTK pathway is well understood, the intracellular protein interaction events that lead to these responses are still not yet well understood.


Related Subjects

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version