alexa Challenges Presented by Re-Emerging Sexually Transmitte
ISSN 2155-6113

Journal of AIDS & Clinical Research
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Research Article

Challenges Presented by Re-Emerging Sexually Transmitted Infections in HIV Positive Men who have Sex with Men: An Observational Study of Lymphogranuloma Venereum in the UK

Minttu Rönn1*, Gwenda Hughes2, Ian Simms2, Cathy Ison3, Sarah Alexander3, Peter J White4,5 and Helen Ward1

1Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK

2STI Section at the Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK

3Sexually Transmitted Bacteria Reference Unit, Public Health England, London, UK

4MRC Centre for Outbreak Analysis and Modelling and NIHR Health Protection Research Unit in Modelling Methodology, Department of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, UK

5Modelling and Economics Unit, Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK

*Corresponding Author:
Minttu Rönn
Department of Infectious Disease Epidemiology
Old Medical School, St. Mary’s Hospital
Norfolk Place, Paddington, London W2 1PG, UK
Tel: +44-(0)20 7594 3290
E-mail: [email protected]

Received Date: May 27, 2014; Accepted Date: July 29, 2014; Published Date: August 06, 2014

Citation: Rönn M, Hughes G, Simms I, Ison C, Alexander S, et al. (2014) Challenges Presented by Re-Emerging Sexually Transmitted Infections in HIV Positive Men who have Sex with Men: An Observational Study of Lymphogranuloma Venereum in the UK. J AIDS Clin Res 5:329. doi:10.4172/2155-6113.1000329

Copyright: © 2014 Rönn M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: United Kingdom has reported the largest documented outbreak of lymphogranuloma venereum (LGV), a re-emerging sexually transmitted infection (STI) which is primarily seen in HIV-positive men who have sex with men (MSM). A diagnostic service was established in response to the outbreak linked to a voluntary LGV Enhanced Surveillance system. We examined the performance of this novel surveillance system to identify utility in tracking a re-emerging infection.

Methods: We described laboratory data on samples and surveillance data from case reports for LGV from 2004- 2010. We performed a cross-sectional analysis comparing clinical and behavioural characteristics of HIV-positive and HIV-negative/unknown LGV cases diagnosed in MSM using multivariable logistic regression models with generalised estimating equations to control for repeat infections.

Results: LGV Surveillance data were available for 87% (1,370/1,581) of LGV cases (after de-duplication). There were 1,342 episodes in 1,281 MSM, most of whom were known to be HIV-positive (1,028/1,281, 80.2%,). HIV-positive men reported a shorter duration of symptoms (aOR 0.5; 95%CI 0.3, 0.8 for reporting more than a week compared to a week or less) in comparison to HIV-negative/unknown MSM, and were more likely to report unprotected receptive anal intercourse (aOR 2.7; 95% CI 1.3, 5.8).

Conclusion: The surveillance identified the population at greater risk of infection based on higher levels of risk behaviour in HIV-positive LGV cases. However, there was diagnostic bias towards HIV-positive LGV cases who presented with a shorter duration of symptoms when compared to HIV-negative/unknown LGV cases.

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