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ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Research Article

Challenging Approach with Nanoformulation and Photodynamic Therapy in Dermatology

Fu-Tang Pan1*, Wei-Zhi Wu1, Qiao-Gui Zhi2 and Qi-Xing Liang1

1Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong 250022, China

2Jinan City Hospital for Dermatologic Disease Prevention and Treatment, Jinan, Shandong 250001, China

*Corresponding Author:
Fu-tang Pan
Shandong Provincial Institute of Dermatology and Venereology
Jinan, Shandong250022, China
Tel: 0086-531-87298882
E-mail: [email protected]

Received date: May 05, 2014; Accepted date: May 30, 2014; Published date: June 06, 2014

Citation: Pan FT, Wu WZ, Zhi QG, Liang QX (2014) Challenging Approach with Nanoformulation and Photodynamic Therapy in Dermatology. J Clin Exp Dermatol Res 5:221. doi: 10.4172/2155-9554.1000221

Copyright: © 2014 Pan FT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background:Photodynamic therapy (PDT) and holds substantial promise in improving outcomes of patients with a form of cutaneous conditions and dermatological conditions such as keratosis and basal cell carcinoma, etc. Use of 5-aminolevulinic acid (ALA) was sanctioned as secure and effective for use as a treatment.

Methods:In our work, we used Photodynamic therapy in patients with selected skin cancerization, and evaluated the fluorescence from photo sensitizer to constitute the field cancerization, which helps in analyzing the efficacy of the technique.

Results:From our study, it is clear that use of ALA with PDT against different skin cancerization has significant effects. However, the effect of efficacy varied according to the type of carcinoma. In our study, we observed that nano- ALA with PDT targeted about 70-80% more skin lesion and the mean reduction area of skin cancerization was about 10% greater with nano-ALA and PDT.

Conclusion:Our findings suggest use of ALA-PDT as a simple, cost effective, and novel method that can be used for various skin cancerization treatments.


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