alexa Chamaecostus subsessilis and Chamaecostus cuspidatus (N
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents

Ezequias Pessoa de Siqueira1*, Jonas Pereira Ramos2, Carlos Leomar Zani1, Albina Carvalho de Oliveira Nogueira3, David Lee Nelson4, Elaine Maria de Souza-Fagundes2 and Betania Barros Cota1
1Laboratory of Chemistry and Natural Products, René Rachou Research Center - FIOCRUZ, Belo Horizonte, MG, Brazil
2Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
3Zoo-Botanic Foundation of Belo Horizonte, Belo Horizonte, MG, Brazil
4Pro-Rectory of Graduate and Research Program, Federal University of Jequitinhonha and Mucuri Valley, Diamantina, MG, Brazil
Corresponding Author : Ezequias Pessoa de Siqueira
René Rachou Research Center
Oswaldo Cruz Foundation
Av. Augusto de Lima
1715, Barro Preto, Belo Horizonte
MG, 30190-002, Brazil
Tel: +553133497791
Fax: +553132953115
E-mail: [email protected]
Received February 02, 2016; Accepted February 12, 2016; Published February 19, 2016
Citation: Siqueira EP, Ramos JP, Zani CL, Nogueira ACO, Nelson DL, et al. (2016) Chamae Costus subsessilis and Chamae Costus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents. Nat Prod Chem Res 4:204. doi:10.4172/2329-6836.1000204
Copyright: © 2016 Siqueira EP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Cytotoxicity activities of the crude ethanol extracts from Chamaecostus subsessilis and Chamaecostus cuspidatus and the fractions obtained by liquid-liquid partition were observed when these species were assayed against a panel of six human cancer cell lineages (HL60, Jurkat, MDA-MB231, MCF-7, HCT, THP-1) and normal (Vero) cells using the MTT colorimetric assay. The cytotoxic effects in the HL60, Jurkat and THP-1 lineages were mediated via an apoptotic mechanism when treated with crude ethanol extracts from these species. The presence of flavonoids, terpenoids and saponins in fractions from both species was observed in the preliminary phytochemical study. These results provide scientific support for the study of the Costaceae family and show that C. cuspidatus and C. subsessilis are potential sources of compounds with anticancer activities.

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