alexa Changes in BDNF and MAPK Signaling Pathways in Experimental Glaucoma
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

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Research Article

Changes in BDNF and MAPK Signaling Pathways in Experimental Glaucoma

Fabiani Carlotta1, Elisa Cerri Sara Ottino2, Marco Sansò2 and Luciano Domenici,3*
1Neuroscience Institute of the National Council of Research (CNR), Pisa, 56100 Pisa, Italy
2ITH S.r.l., 56125 Pontedera, Pisa, Italy
3Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, 67100 L'Aquila, Italy
*Corresponding Author : Luciano Domenici, MD, PhD
CNR Neuroscience Institute
Via G. Moruzzi
56100 Pisa, Italy
E-mail: [email protected]
Received date: December 29, 2015; Accepted date: March 22, 2016; Published date: March 25, 2016
Citation: Carlotta F, Sara Ottino EC, Sansò M, Domenici L (2016) Changes in BDNF and MAPK Signaling Pathways in Experimental Glaucoma. J Clin Exp Ophthalmol 7:530. doi:10.4172/2155-9570.1000530
Copyright: © 2016 Carlotta F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Glaucoma is currently recognized to be a multifactorial, progressive, neurodegenerative disorder. It is characterized by the retinal ganglion cells (RGCs) loss of axons as well as optic nerve atrophy, progressive degeneration of RGCs till cell death. In this work, we used DBA/2J mice as a model of spontaneous glaucoma and we investigated the involvement of BDNF and Mitogen-Activated Protein Kinases (MAPK) pathways in correlation with IOP elevation and progression of neurodegenerative processes in the retina of DBA/2J mice. In particular, we performed western blot analysis to study retinal levels of the BDNF and its receptor, TrkB, and to better understand possible modulation of p38 MAPK and ERK1/2 activation at different stages of retinal degeneration in DBA/2J mice. We showed that BDNF starts to decrease already at an early stage in correspondence to IOP elevation (7 months of age). MAPKs, in particular p38 MAPK and ERK1/2, appeared maximally affected at more advanced stages of neurodegeneration (10-12 and 18 months of age) characterized by RGC degeneration and death, optic nerve atrophy. Thus, BDNF signaling and MAPKs are differentially activated at different stages of retinal degeneration in DBA/2J mice, a murine model of glaucoma.

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