alexa Changes in Body Mass Index Following HAART Initiation among HIVInfected Women in the Women’s Interagency HIV Study
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Changes in Body Mass Index Following HAART Initiation among HIVInfected Women in the Women’s Interagency HIV Study

Anjali Sharma1*, Shalanda A Bynum2, Michael F Schneider3, Christopher Cox3, Phyllis C Tien4, Ronald C Hershow5, Deborah Gustafson6 and Michael W Plankey7

1Departments of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

2Social and Behavioral Sciences, Uniformed Services University of the Health Sciences, Bethesda, USA

3Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

4Medicine, University of California at San Francisco, USA

5Epidemiology, University of Illinois at Chicago, USA

6 Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA

7Medicine, Division of Infectious Diseases, Georgetown University Medical Center, Washington, DC, USA

*Corresponding Author:
Anjali Sharma
Albert Einstein College of Medicine
1300 Morris Park Ave, Block Bldg #305
Bronx, NY 10461, USA
Tel: 718-430-2067
Fax: 718-430-4035
E-mail: [email protected]

Received Date: May 21, 2014; Accepted Date: June 25, 2014; Published Date: July 07, 2014

Citation: Sharma A, Bynum SA, Schneider MF, Cox C, Tien PC, et al. (2014) Changes in Body Mass Index Following HAART Initiation among HIV-Infected Women in the Women’s Interagency HIV Study. J AIDS Clin Res 5:323. doi:10.4172/2155-6113.1000323

Copyright: © 2014 Sharma A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: Examine changes in, and factors associated with changing body mass index (BMI) in women following highly active antiretroviral therapy (HAART) initiation. Methods: 1177 HIV-infected Women’s Interagency HIV Study participants who contributed 10,754 years of followup following HAART initiation were studied. Changes in median BMI up to 15 years following HAART initiation, and the highest and lowest BMI reached following HAART initiation were summarized by pre-HAART BMI category (<18.5 [underweight], 18.5-<25.0 [normal weight], 25.0-<30.0 [overweight], 30.0-<40.0 [obese], and ≥ 40.0 [morbidly obese]). Multivariate mixed effects ordinal logistic regression estimated the degree of association of each exposure of interest with post-HAART BMI. Results: Before HAART, 39% percent of women had normal BMI, 31% were overweight, 23% were obese, and 5% were morbidly obese. Following HAART initiation, median BMI change (per 5 years) was 0.21 kg/m2 (90% confidence interval [CI]: -1.33, 0.42) for those with normal pre-HAART BMI, 0.39 kg/m2 (90% CI: 0.15,0.66) for overweight, 0.31 kg/ m2 (90% CI: -1.18,0.67) for obese, and -0.36kg/m2 for morbidly obese women. After initiating HAART, 40% with normal pre-HAART BMI became overweight at some point; of those overweight, 46% remained overweight and 47% became obese; 71% of obese women remained obese and 27% became morbidly obese. Each year of nucleoside analog reverse transcriptase inhibitor use was associated with a 3% decreased odds of reaching a higher BMI category (OR 0.97, 95% CI: 0.95, 0.99), while each year of protease inhibitor or non-nucleoside analog reverse transcriptase inhibitor use were associated with a 6% (OR 1.06, 95% CI: 1.04, 1.08) and 5%(OR 1.05, 95% CI: 1.01, 1.08) increased odds of having a higher BMI category, respectively. Conclusions: Although overweight and obesity are highly prevalent in this large cohort of HIV-infected, minority women, HAART use was associated with only a modest increase in BMI over time.

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