alexa Changes in Chromatin Structure along Aging
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
Open Access

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Review Article

Changes in Chromatin Structure along Aging

Alberto da Silva Moraes*
Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, MG, Brazil
Corresponding Author : Alberto S Moraes
Cytology, Histology, and Embryology Section
Institute of Biomedical Sciences
Federal University of Uberlandia
Av Para, 1720, Building 2B, 2nd floor
Bairro Umuarama, Uberlandia, Minas
Gerais, 38400-902, Brazil
Tel: +55343218-2240
Fax: +55343218-2240
E-mail: [email protected]
Received March 17, 2014; Accepted May 01, 2014; Published May 03, 2014
Citation: Moraes AS (2014) Changes in Chromatin Structure along Aging. J Gerontol Geriat Res 3:157.doi:10.4172/2167-7182.1000157
Copyright: © 2014 Moraes AS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

In a world with an increasing aging population, a proper understanding of the biology of the aging process could be of economic and social significance for governments, in order to guarantee a long but productive life for the elderly. In this regard, studies about the relationship between changes in chromatin organization and aging are pivotal, since it has been widely accepted that the aging process can be genetically driven. Several studies have shown that aging is associated with changes in gene expression and chromatin structure, and that in many cases, including diseases; such phenotypes can be pharmacologically altered in order to reestablish homeostasis. Therefore, the objective of this review was to analyze what has been published in this subject from a historical perspective, and to discuss what can be concluded from those results with its impact in human health.

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