Changes in Interleukin-6 and Highly Sensitive C-Reactive Protein in Patients who Underwent Redo Coronary Artery Bypass Grafting
|Stojkovic Branislav1, Vukovic Petar2, Milojevic Predrag2, Jovanovic Toma1, Calija Branko2, Maravic-Stojkovic Vera2*, Djukanovic Bosko2and Jelena Marinkovic3|
|1Institute of Physiology, Belgrade University School of Medicine, Belgrade, R Serbia|
|2Dedinje Cardiovascular Institute, Belgrade University School of Medicine, Belgrade, R Serbia|
|3Institute of Medical Statistics and Informatics, Belgrade University School of Medicine, Belgrade, R Serbia|
|Corresponding Author :||Maravic-Stojkovic Vera, MD, Ph.D
Dedinje Cardiovascular Institute
M. Tepica 1, 11 000 Belgarde, R Serbia
Tel: +381 11 3601 675
Fax: +381 11 3601 676
E-mail: [email protected]
|Received May 24, 2012; Accepted June 27, 2012; Published June 30, 2012|
|Citation: Branislav S, Petar V, Predrag M, Toma J, Branko C, et al. (2012) Changes in Interleukin-6 and Highly Sensitive C-Reactive Protein in Patients who Underwent Redo Coronary Artery Bypass Grafting. J Clin Exp Cardiolog S7:003.doi: 10.4172/2155-9880.S7-003|
|Copyright: © 2012 Branislav S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Determination of biomarkers can assess cardiac injury induced by cardiopulmonary bypass (CPB) during coronary artery bypass grafting (CABG). Open heart surgery initiates inflammatory reaction. Aim of this study was to compare the inflammatory response in patients undergoing first- and CABG-reoperation.
Methods: Fifty-four patients (16% female, 84% male; 60.5 ± 6.5 vs. 66.2 ± 7.3 years) scheduled for elective cardiac surgery were divided into: Group 1, CABG primo-operation, and Group 2, CABG re-operation (redo CABG). The extent of inflammation was estimated by measuring interleukin (IL)-6 and highly sensitive C-reactive protein (hs- CRP) in plasma. Blood samples were collected: 24 hours prior, 6, and 24 hours after initiation of CPB. Demographic data, preoperative risk assessment Euro-score, laboratory values and clinical outcomes: atrial fibrillation rate, tracheal intubation time, revisions, blood loss, length of Intensive Care Unit (ICU) and hospital stay were analyzed.
Results: Baseline levels of IL-6 (p < 0.001) were significantly higher in re-operated patients. IL-6 increased significantly 6 hours after initiation of CPB in both groups (p < 0.0001). Day after surgery IL-6 (p = 0.472) and hs- CRP (p = 0.248) levels were similar in both groups. Although hs-CRP was higher in Group 1 (90.45 ± 46.67 vs. 72.91 ± 57.31 mg/L) this had no statistical significance. Clinical outcomes have been in positive correlations with inflammation, but statistically insignificant in both groups.
Conclusion: Monitoring of IL-6 and hs-CRP during redo CABG has shown that CPB cause inflammatory reaction but repeated use does not cause extensive reaction potentially harmful for myocardium.